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- Title
Cervical Squamous Cell Carcinoma Diagnosis by FTIR Microspectroscopy.
- Authors
Félix, Maria M.; Tavares, Mariana V.; Santos, Inês P.; Batista de Carvalho, Ana L. M.; Batista de Carvalho, Luís A. E.; Marques, Maria Paula M.
- Abstract
Cervical cancer was considered the fourth most common cancer worldwide in 2020. In order to reduce mortality, an early diagnosis of the tumor is required. Currently, this type of cancer occurs mostly in developing countries due to the lack of vaccination and screening against the Human Papillomavirus. Thus, there is an urgent clinical need for new methods aiming at a reliable screening and an early diagnosis of precancerous and cancerous cervical lesions. Vibrational spectroscopy has provided very good results regarding the diagnosis of various tumors, particularly using Fourier transform infrared microspectroscopy, which has proved to be a promising complement to the currently used histopathological methods of cancer diagnosis. This spectroscopic technique was applied to the analysis of cryopreserved human cervical tissue samples, both squamous cell carcinoma (SCC) and non-cancer samples. A dedicated Support Vector Machine classification model was constructed in order to categorize the samples into either normal or malignant and was subsequently validated by cross-validation, with an accuracy higher than 90%.
- Subjects
SQUAMOUS cell carcinoma; HUMAN papillomavirus; MEDICAL screening; DIAGNOSIS; SUPPORT vector machines
- Publication
Molecules, 2024, Vol 29, Issue 5, p922
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules29050922