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- Title
A Single Organic Fluorescent Probe for the Discrimination of Dual Spontaneous ROS in Living Organisms: Theoretical Approach.
- Authors
Fu, Liang; Huang, He; Zuo, Zhongfu; Peng, Yongjin
- Abstract
Single-organic-molecule fluorescent probes with double-lock or even multi-lock response modes have attracted the attention of a wide range of researchers. The number of corresponding reports has rapidly increased in recent years. The effective application of the multi-lock response mode single-molecule fluorescent probe has improved the comprehensive understanding of the related targets' functions or influences in pathologic processes. Building a highly efficient functional single-molecule fluorescent probe would benefit the diagnosis and treatment of corresponding diseases. Here, we conducted a theoretical analysis of the synthesizing and sensing mechanism of this kind of functional single-molecule fluorescent probe, thereby guiding the design and building of new efficient probes. In this work, we discuss in detail the electronic structure, electron excitation, and fluorescent character of a recently developed single-molecule fluorescent probe, which could achieve the discrimination and profiling of spontaneous reactive oxygen species (ROS, •OH, and HClO) simultaneously. The theoretical results provide insights that will help develop new tools for fluorescent diagnosis in biological and medical fields.
- Subjects
FLUORESCENT probes; ELECTRONIC excitation; REACTIVE oxygen species; PATHOGENESIS; ELECTRONIC structure; INTRAMOLECULAR proton transfer reactions
- Publication
Molecules, 2023, Vol 28, Issue 19, p6983
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules28196983