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- Title
Phytochemical Analysis and In Vitro Antileukemic Activity of Alkaloid-Enriched Extracts from Vinca sardoa (Stearn) Pignatti.
- Authors
De Vita, Daniela; Frezza, Claudio; Sciubba, Fabio; Toniolo, Chiara; Badiali, Camilla; Petrucci, Rita; Bortolami, Martina; Di Matteo, Paola; Rocco, Daniele; Stringaro, Annarita; Colone, Marisa; Maxia, Andrea; Petrucci, Maria Teresa; Serafini, Mauro; Foddai, Sebastiano
- Abstract
Vinca sardoa (Stearn) Pignatti, known as Sardinian periwinkle, is widely diffused in Sardinia (Italy). This species contains indole alkaloids, which are known to have a great variety of biological activities. This study investigated the antileukemic activity against a B lymphoblast cell line (SUP-B15) of V. sardoa alkaloid-rich extracts obtained from plants grown in Italy, in Iglesias (Sardinia) and Rome (Latium). All the extracts showed a good capacity to induce reductions in cell proliferation of up to 50% at the tested concentrations (1–15 µg/mL). Moreover, none of the extracts showed cytotoxicity on normal cells at all the studied concentrations.
- Subjects
SARDINIA (Italy); ROME; ITALY; PHYTOCHEMICALS; INDOLE alkaloids; B cells; EXTRACTS; CELL proliferation; CELL lines
- Publication
Molecules, 2023, Vol 28, Issue 15, p5639
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules28155639