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- Title
Detection of anti-Candida albicans IgE antibodies in vaginal washes from patients with acute vulvovaginal candidiasis.
- Authors
Regúlez, P; García Fernández, J F; Moragues, M D; Schneider, J; Quindós, G; Pontón, J
- Abstract
Vaginal washes from 55 women were investigated by means of an ELISA method for the presence of IgE antibodies against Candida albicans. These antibodies were detected in 87.1% of patients with clinical acute vulvovaginal candidiasis (group I), 100% of patients with suspected vulvovaginal candidiasis but negative by microscopy and culture (group II), 0% of asymptomatic carriers (group III) and 33.3% of uninfected controls (group IV). Statistically significant differences were observed comparing groups I and II vs. groups III and IV. The highest IgE vaginal antibody titers were mostly at the expense of serotype A C. albicans strains, which represented 83.3% of the C. albicans isolates. Non-C. albicans species also showed very low IgE levels. No correlation between serum and vaginal IgE was found. Furthermore, a second determination of vaginal IgE levels was performed in 3 patients. A decrease in IgE levels concomitant to a decline in clinical symptoms was observed in all of them after treatment.
- Subjects
IMMUNOGLOBULIN analysis; CANDIDA albicans; VULVOVAGINAL candidiasis; COMPARATIVE studies; IRRIGATION (Medicine); RESEARCH methodology; MEDICAL cooperation; PAP test; RESEARCH; EVALUATION research; ACUTE diseases
- Publication
Gynecologic & Obstetric Investigation, 1994, Vol 37, Issue 2, p110
- ISSN
0378-7346
- Publication type
journal article