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- Title
Uterine Artery Pulsatility Index Assessment at <11 Weeks' Gestation: A Prospective Study.
- Authors
Taylor, Tracey J.; Quinton, Ann E.; de Vries, Bradley S.; Hyett, Jonathon A.; Taylor, Tracey J; Quinton, Ann E; de Vries, Bradley S; Hyett, Jonathon A
- Abstract
<bold>Objective: </bold>Mean uterine artery pulsatility index (meanUAPI) is commonly measured at 11-13+6 weeks to predict adverse pregnancy outcomes including hypertensive disorders and small-for-gestational age. The aims of this study were to establish a population-specific reference range for meanUAPI at <11 weeks, to determine if an abnormal meanUAPI at <11 weeks was associated with adverse pregnancy outcome, and to assess changes in meanUAPI between <11 weeks and 11-13+6 weeks.<bold>Methods: </bold>A prospective cohort was examined at <11 weeks and at 11-13+6 weeks to develop reference ranges for meanUAPI. Based on these regression models, meanUAPI Z-scores were compared between outcome groups using a two-sample t test. Longitudinal changes in the meanUAPI between <11 and 11-13+6 weeks were assessed by two-way mixed ANOVA.<bold>Results: </bold>Prior to 11 weeks, there was no significant difference in meanUAPI between normal (n = 622) and adverse (n = 80) outcomes (mean [95% CI]: 2.62 [2.57-2.67] and 2.67 [2.50-2.84], respectively; p = 0.807). At 11-13+6 weeks, meanUAPI was significantly higher in the adverse (n = 66) compared with the normal (n = 535) outcome group (mean [95% CI]: 1.87 [1.70-2.03] and 1.67 [1.63-1.72], respectively; p = 0.040). There was a statistically significant decrease (p < 0.0001) in meanUAPI between the two time points.<bold>Conclusion: </bold>MeanUAPI measured at <11 weeks' gestation does not appear to be a useful marker for the prediction of placental-related adverse pregnancy outcomes, supporting an argument for the prediction of risk at 11-13+6 weeks' gestation.
- Subjects
UTERINE artery; PREGNANCY; LONGITUDINAL method; TWO-way analysis of variance; REGRESSION analysis
- Publication
Fetal Diagnosis & Therapy, 2020, Vol 47, Issue 2, p129
- ISSN
1015-3837
- Publication type
journal article
- DOI
10.1159/000500776