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- Title
Regulation of inflammasome signaling.
- Authors
Rathinam, Vijay A K; Vanaja, Sivapriya Kailasan; Fitzgerald, Katherine A
- Abstract
Innate immune responses have the ability to both combat infectious microbes and drive pathological inflammation. Inflammasome complexes are a central component of these processes through their regulation of interleukin 1? (IL-1?), IL-18 and pyroptosis. Inflammasomes recognize microbial products or endogenous molecules released from damaged or dying cells both through direct binding of ligands and indirect mechanisms. The potential of the IL-1 family of cytokines to cause tissue damage and chronic inflammation emphasizes the importance of regulating inflammasomes. Many regulatory mechanisms have been identified that act as checkpoints for attenuating inflammasome signaling at multiple steps. Here we discuss the various regulatory mechanisms that have evolved to keep inflammasome signaling in check to maintain immunological balance.
- Subjects
INFLAMMATION; CELLULAR signal transduction; IMMUNE response; BACTERIAL diseases; INTERLEUKIN-1; CELL death; INTERLEUKIN-18
- Publication
Nature Immunology, 2012, Vol 13, Issue 4, p333
- ISSN
1529-2908
- Publication type
Article
- DOI
10.1038/ni.2237