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- Title
Activation and accumulation of B cells in TACI-deficient mice.
- Authors
Yan, Minhong; Wang, Hua; Chan, Betty; Roose-Girma, Meron; Erickson, Sharon; Baker, Thad; Tumas, Daniel; Grewal, Iqbal S.; Dixit, Vishva M.
- Abstract
The tumor necrosis factor (TNF)-related ligand B lymphocyte stimulator (BLyS) binds two TNF receptor family members, transmembrane activator and calcium-modulating and cyclophilin ligand interactor (TACI) and B cell maturation molecule (BCMA). Mice that are transgenic for BLyS show B cell accumulation, activation and autoimmune lupus-like nephritis. The existence of at least two distinct BLyS receptors raises the question of the relative contribution of each to B cell functions. We therefore generated mice that were deficient in TACI. TACI-/- mice showed increased B cell accumulation and marked splenomegaly. Isolated TACI-/- B cells hyperproliferated and produced increased amounts of immunoglobulins in vitro. In vivo antigen challenge resulted in enhanced antigen-specific antibody production. Thus, TACI may play an unexpected inhibitory role in B cell activation that helps maintain immunological homeostasis.
- Subjects
B cells; TUMOR necrosis factors
- Publication
Nature Immunology, 2001, Vol 2, Issue 7, p638
- ISSN
1529-2908
- Publication type
Article
- DOI
10.1038/89790