We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Genetic manipulation of secondary metabolite biosynthesis for improved production in Streptomyces and other actinomycetes.
- Authors
Baltz, Richard
- Abstract
Actinomycetes continue to be important sources for the discovery of secondary metabolites for applications in human medicine, animal health, and crop protection. With the maturation of actinomycete genome mining as a robust approach to identify new and novel cryptic secondary metabolite gene clusters, it is critical to continue developing methods to activate and enhance secondary metabolite biosynthesis for discovery, development, and large-scale manufacturing. This review covers recent reports on promising new approaches and further validations or technical improvements of existing approaches to strain improvement applicable to a wide range of Streptomyces species and other actinomycetes.
- Subjects
METABOLITES; METABOLITE synthesis; STREPTOMYCES; ACTINOBACTERIA; DRUG development; ANIMAL health; GENOMICS; BIOSYNTHESIS
- Publication
Journal of Industrial Microbiology & Biotechnology, 2016, Vol 43, Issue 2/3, p343
- ISSN
1367-5435
- Publication type
Article
- DOI
10.1007/s10295-015-1682-x