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- Title
IMUNOSNI ODGOVORI KOŽE USLIJED Leishmania spp. INVAZIJE (1).
- Authors
Štimac, Iva; Martinković, Franjo
- Abstract
Infection by parasites of the genus Leishmania results in the development of leishmaniases, an increasingly prevalent group of diseases affecting large numbers of people worldwide. Leishmaniasis can have very different outcomes ranging from cutaneous lesions, mucosal lesions to visceralization, depending on the species of the infecting parasite and on the immune response developed by the host. As an obligate intracellular parasite residing within macrophages, Leishmania evolved in strict contact with the host immune system, developing different mechanisms to evade or modulate the immune response. Various types of immune responses are observed during different Leishmania spp. infections, resulting in parasite clearance, but also contributing to the pathogenesis, thus increasing the complexity of the course of the disease. As a protective interface between internal organs and the environment, the skin encounters a host of toxins, pathogenic organisms and physical stresses. To combat these attacks on the cutaneous microenvironment, the skin functions as more than a physical barrier - it is an active immune organ. Immune responses in the skin involve an armamentarium of immune-competent cells and soluble biologic response modifiers including cytokines. The main task of the skin-resident immune cells is the containment of the invading pathogen to the skin to prevent spreading to inner organs and/or the elimination of the pathogen if possible.
- Subjects
LEISHMANIASIS; LEISHMANIA; IMMUNE response; INTRACELLULAR pathogens; PHYSIOLOGICAL stress; IMMUNE system; DISEASE progression
- Publication
Veterinaria, 2022, Vol 71, Issue 2, p255
- ISSN
0372-6827
- Publication type
Article
- DOI
10.51607/22331360.2022.71.2.255