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- Title
乳蛋白部分水解配方奶粉在过敏高风险新生儿的临床研究.
- Authors
魏克伦; 郝丽红; 刘 雷; 俞志凌; 郑安洁; 王珊珊
- Abstract
Objective To observe the effects of partially hydrolyzed formulas (pHFs) on the physical development and allergic reaction of infants with high risk of allergy aged from 0 to 3 months. Methods Infants with high risk genetic allergy background born in maternity hospitals and maternity departments in general hospitals from Sheny ang and Tianjin between January to September, 2019 were included and divided into general formula feeding group (group A), breast-feeding group (group B ) and pHF-feeding group (group C) according to their families' wishes. Physical growth and allergic reaction were followed up in 4 weeks and 12 weeks and the differences in them were analyzed. Results A total of 806 infants were included, including 84 infants in group A, 362 infants in group B and 360 infants in group C. Weight, body length or head circumference had no significant differences among the three groups at 0 week 4 weeks or 12 weeks (P > 0. 05). Totally, 196 infants had allergic reactions within 12 weeks, among which group A (35. 7% ) was significantly higher than group B (26. 8% ) and group C (19. 2%) (P = 0. 002 1) . Univariate logistic regression analysis showed that the risk of anaphylaxis in group C was 0.43 times than that of group A (OR = 0. 43, 95% Cl;0. 25 ~ 0. 72, P = 0. 001 3), while the risk of allergic reaction was only 0. 28 and 0. 26 for pHF ( OR = 0. 28, 95% Cl;O. 12 ~ 0. 66, P =0. 003 8) and breast-feeding (OR= 0. 26, 95% Cl;0. 11 ~ 0. 62, p = 0. 002 6) after ad justing for gender, methods of delivery, gestational age, birth weight, and maternal age. Conclusion pHF-feeding can meet the physical development needs of infants and reduce the risk of allergic reaction aged between 0 to 3 months.
- Publication
Practical Pharmacy & Clinical Remedies, 2020, Vol 23, Issue 9, p817
- ISSN
1673-0070
- Publication type
Article
- DOI
10.14053/j.cnki.ppcr.202009011