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- Title
Dextran/Albumin hydrogel sealant for Dacron® vascular prosthesis.
- Authors
Lisman, Anna; Butruk, Beata; Wasiak, Iga; Ciach, Tomasz
- Abstract
In this paper, the authors describe a novel type of hydrogel coating prepared from the copolymer of human serum albumin and oxidized dextran. The material was designed as a hydrogel sealant for polyester (Dacron®)-based vascular grafts. Dextran was chosen as a coating material due to its anti-thrombogenic properties. Prepared hydrogels were compared with similar, already known biomaterial made from gelatine with the same cross-linking agent. Obtained hydrogels, prepared from various ratios of oxidized dextran/albumin or oxidized dextran/gelatine, showed different cross-linking densities, which caused differences in swelling, degradation rate and mechanical properties. Permeability tests confirmed the complete tightness of the hydrogel-modified prosthesis. Results showed that application of the hydrogel coating provided leakage-free prosthesis and eliminated the need of pre-clotting.
- Subjects
DEXTRAN; HYDROGELS; SEALING compounds; DACRON; PROSTHETICS; SERUM albumin; COPOLYMERS; CROSSLINKING (Polymerization)
- Publication
Journal of Biomaterials Applications, 2014, Vol 28, Issue 9, p1386
- ISSN
0885-3282
- Publication type
Article
- DOI
10.1177/0885328213509676