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- Title
Molecular Status of Plasma Fibronectin as an Additional Biomarker for Assessment of Alzheimer’s Dementia Risk.
- Authors
Lemañska-Perek, Anna; Leszek, Jerzy; Krzyżanowska-Gołąb, Dorota; Radzik, Jacek; Kątnik-Prastowska, Iwona
- Abstract
Background:Aberrant angiogenesis and senescence of the cerebrovascular system could initiate neurovascular events leading to neurovascular disorders. Fibronectin (FN) exerts a strong angiogenic influence on endothelial cells in the central nervous system. Methods: In the present study the expression of the plasma fibronectin molecular forms in an Alzheimer patient group, compared with vascular dementia and age-matched control groups was analyzed by immunoblotting. Results: FN in the plasma of the elderly individuals with and without dementia exists as a mixture of heterogeneous molecules with increasing molecular masses. Apart from the wide ∼240-kDa and ∼220-kDa FN bands, normally present in plasma, the high molecular FN forms having ∼280 kDa and ∼320 kDa appeared in the plasma of the Alzheimer dementia group more frequently and at the higher amounts than in the vascular dementia and age-matched nondemented groups. Conclusions: The plasma FN molecular status seems to be a molecular additional biomarker for assessment of dementia risk. Copyright © 2009 S. Karger AG, Basel
- Subjects
NEOVASCULARIZATION; CELLS; CENTRAL nervous system; ALZHEIMER'S disease; DEMENTIA; IMMUNOBLOTTING; DISEASES in older people
- Publication
Dementia & Geriatric Cognitive Disorders, 2009, Vol 28, Issue 4, p338
- ISSN
1420-8008
- Publication type
Article
- DOI
10.1159/000252764