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- Title
Cognitive Deficits and Polymorphism of Apolipoprotein E in Alzheimer's Disease.
- Authors
Łuczywek, Elżbieta; Nowicka, Anna; Pfeffer, Anna; Czyżewski, Krzysztof; Styczyńska, Maria; Łałowski, Maciej; Barcikowska, Maria
- Abstract
The aim of this study was to test the relationship between apolipoprotein E (ApoE) genotypes and patterns of cognitive deficits in Alzheimer's disease (AD). All subjects were diagnosed as probable AD patients on the basis of the DSM-IV and NINCDS-ADRDA criteria. Each subject was examined for (1) ApoE genotype, (2) general level of mental activity (Global Deterioration Scale and Mini-Mental State Examination) and (3) cognitive functions by means of a battery of neuropsychological tests. On the basis of ApoE genotype, patients were subdivided into two groups: the first group consisted of patients with at least one ε4 allele (ε4+ group), while the second one consisted of patients without the ε4 allele (ε4- group). Our results showed that several cognitive processes depended on the ApoE genotype. In early stages of AD, patients from the ε4+ group had greater deficits in delayed recall of new information. On the other hand, working memory appeared to be more impaired in the ε4- group of patients. Independent of the genotype, both groups showed similar impairment of learning ability without, however, deficits in remote memory. Copyright © 2002 S. Karger AG, Basel
- Publication
Dementia & Geriatric Cognitive Disorders, 2002, Vol 13, Issue 3, p171
- ISSN
1420-8008
- Publication type
Article
- DOI
10.1159/000048649