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- Title
Meta-analysis of methylprednisolone pulse therapy for Graves' ophthalmopathy.
- Authors
Gao, Guohong; Dai, Jinhui; Qian, Yifeng; Ma, Fei
- Abstract
A meta-analysis was performed to evaluate the efficacy of methylprednisolone pulse therapy for Graves' ophthalmopathy. Eight studies involving 376 patients were included. A higher effective rate was found for patients treated with intravenous glucocorticoids ( IVGC) over oral glucocorticoids (OGC) (risk ratio [ RR] = 1.48; 95% confidence interval [ CI] = 1.18−1.86). The combined IVGC and orbital radiotherapy ( OR) was markedly more effective than OGC+OR ( RR = 1.40; 95% CI = 1.11−1.77). IVGC resulted in an obvious reduction of clinical activity score (CAS) compared with OGC, with a weighted mean difference ( WMD) of 0.86 (95% CI = 0.53−1.18). The WMD for the reduction of the CAS between IVGC+ OR and OGC+ OR was 0.66 (95% CI = 0.30−1.02). IVGC is an effective treatment and cause fewer adverse events. Limiting the total cumulative dose of methylprednisolone, careful patient selection and monitoring the condition of patients during treatment are necessary.
- Subjects
THYROID eye disease; METHYLPREDNISOLONE; TREATMENT effectiveness; META-analysis; OPHTHALMOLOGY; THERAPEUTICS
- Publication
Clinical & Experimental Ophthalmology, 2014, Vol 42, Issue 8, p769
- ISSN
1442-6404
- Publication type
Article
- DOI
10.1111/ceo.12317