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- Title
Human Adenovirus Type 7 Infections in Hubei, China During 2018-2019: Epidemic Features and Genetic Characterization of the Detected Viruses.
- Authors
Li, Ying; Wang, Decheng; Zhang, Jingjing; Huang, Peiqi; Du, Hui; Xu, Jiali; Chen, Hebin; Yan, Yi; Chen, Hongwei; Lu, Xiaoxia; Liu, Di
- Abstract
Human adenoviruses (HAdVs) type 7 can cause severe respiratory disease. During the period between December 2018 and August 2019, HAdV-7 infection was identified in 129 patients in Wuhan Children's Hospital, Hubei Province, China. Samples were collected from hospitalized children and metagenomic sequencing was applied to detect the HAdV infections. Hemophagocytic lymphohistiocystosis (HLH) related to HAdV infections was observed in some patients clinically and patients were divided into two groups based on this to test the differences among clinical indicators. Genome variation, in silico restriction endonuclease analysis (REA), and phylogenetic analyses were carried out to show the genome characterization of HAdV-7 in this study. It was found that many indicators, such as all blood routine indicators, in patients of the HLH group showed significant levels. In this study, REA revealed that HAdV-7 might belong to genome 7d and genome variation analysis displayed the stable genome of HAdV. HAdV-7 is an ongoing threat to the public, and global surveillance should be established.
- Subjects
HUBEI Sheng (China); WUHAN (China); COVID-19; SARS-CoV-2; ADENOVIRUSES; HOSPITAL care of children; HUMAN adenoviruses; CHILDREN'S hospitals; EPIDEMICS
- Publication
Frontiers in Cellular & Infection Microbiology, 2021, Vol 11, p1
- ISSN
2235-2988
- Publication type
Article
- DOI
10.3389/fcimb.2021.684606