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- Title
Desmosomal adhesion regulates epithelial morphogenesis and cell positioning.
- Authors
Runswick, Sarah K.; O'Hare, Mike J.; Jones, Louise; Streuli, Charles H.; Garrod, David R.
- Abstract
Desmosomes are intercellular junctions of epithelia and are of widespread importance in the maintenance of tissue architecture. We provide evidence that desmosomal adhesion has a function in epithelial morphogenesis and cell-type-specific positioning. Blocking peptides corresponding to the cell adhesion recognition (CAR) sites of desmosomal cadherins block alveolar morphogenesis by epithelial cells from mammary lumen. Desmosomal CAR-site peptides also disrupt positional sorting of luminal and myoepithelial cells in aggregates formed by the reassociation of isolated cells. We demonstrate that desmosomal cadherins and E-cadherin are comparably involved in epithelial morphoregulation. The results indicate a wider role for desmosomal adhesion in morphogenesis than has previously been considered.
- Subjects
DESMOSOMES; CELL adhesion; EPITHELIUM; MORPHOGENESIS
- Publication
Nature Cell Biology, 2001, Vol 3, Issue 9, p823
- ISSN
1465-7392
- Publication type
Article
- DOI
10.1038/ncb0901-823