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- Title
NMDA receptors are critical for unleashing consolidated auditory fear memories.
- Authors
Mamou, Cyrinne Ben; Gamache, Karine; Nader, Karim
- Abstract
Memories are dynamic and can change when recalled. The process that returns memories to a labile state during remembering is unclear. We found that the presence of NMDA, but not AMPA, receptor antagonists in the amygdala prior to recall prevented the consolidated fear memory from returning to a labile state. These findings suggest that NMDA receptors in the amygdala are critical for transforming a memory from a fixed to a labile state.
- Subjects
MEMORY; FEAR; RECOLLECTION (Psychology); METHYL aspartate; CELL receptors; AMYGDALOID body
- Publication
Nature Neuroscience, 2006, Vol 9, Issue 10, p1237
- ISSN
1097-6256
- Publication type
Article
- DOI
10.1038/nn1778