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- Title
High frequency, synchronized bursting drives eye-specific segregation of retinogeniculate projections.
- Authors
Torborg, Christine L; Hansen, Kristi A; Feller, Marla B
- Abstract
Blockade of retinal waves prevents the segregation of retinogeniculate afferents into eye-specific layers in the visual thalamus. However, the key features of retinal waves that drive this refinement are controversial. Some manipulations of retinal waves lead to normal eye-specific segregation but others do not. By comparing retinal spiking patterns in several mutant mice with differing levels of eye-specific segregation, we show that the presence of high-frequency bursts synchronized across neighboring retinal ganglion cells correlates with robust eye-specific segregation and that the presence of high levels of asynchronous spikes does not inhibit this segregation. These findings provide a possible resolution to previously described discrepancies regarding the role of retinal waves in retinogeniculate segregation.
- Subjects
ALDEHYDES; RETINAL (Visual pigment); RETINOIDS; NEUTRAL trade with belligerents; SENSORY ganglia; OPTIC nerve cytology
- Publication
Nature Neuroscience, 2005, Vol 8, Issue 1, p72
- ISSN
1097-6256
- Publication type
Article
- DOI
10.1038/nn1376