We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Protecting effects of a large dose of dexamethasone on spleen injury of rats with severe acute pancreatitis.
- Authors
Zhang Xiping; Zhang Ruiping; Yu Binyan; Zhou Li; Chen Hanqing; Zhu Wei; Ying Rongchao; Ye Jing; Yuan Wenqin; Bai Jinjin
- Abstract
Background and Aims: To explore the protecting effects and mechanisms of dexamethasone on spleen injury in rats with severe acute pancreatitis (SAP). Methods: The rats were randomly divided into a model control group, treated group and sham-operated group. The contents of plasma endotoxin, serum NO, phospholipase A2 enzyme (PLA2) and endothelin-1 (ET-1) were determined. The mortality rate, pathological changes and changes of Bax and Bcl-2 protein expression levels and apoptotic indexes in the spleen of rats were observed in all groups, respectively, at 3, 6 and 12 h after operation. Results: Although the survival rate was significantly higher in the treated group than in the model control group, there was no significantly different between them ( P > 0.05). The expression levels of Bax and Bcl-2 proteins and apoptotic indexes were significantly higher in the treated group than in the model control group at different time points ( P < 0.05 or P < 0.01) while other blood indexes contents and pathological severity scores of spleen were significantly lower in the treated group than in the model control group ( P < 0.05, P < 0.01 or P < 0.001). Conclusion: Dexamethasone can protect spleen from injury during SAP mainly by reducing the content of inflammatory mediators in blood.
- Subjects
DEXAMETHASONE; SPLEEN injuries; PANCREATITIS; ENDOTOXINS; PHOSPHOLIPASES
- Publication
Journal of Gastroenterology & Hepatology, 2010, Vol 25, Issue 2, p302
- ISSN
0815-9319
- Publication type
Article
- DOI
10.1111/j.1440-1746.2009.05999.x