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- Title
PRESENCE OF HELICOBACTER PYLORI IN BILE AND BILE DUCT MALIGNACIES.
- Authors
Bulajic, Milutin; Jovanovic, Ivan; Lohr, Matthias
- Abstract
Objective To evaluate the role of H. p in biliary malignancies, in conjunctions with smoking and coffee consumption habits. Material & Methods 89 patients (m = 41, f = 47; AGE 57.7 ± 16.4), referred to the clinic for diagnosis of hepatobiliary diseases. All the patients underwent full clinical workup, including anamnestic data on smoking and coffee consumption habits. The fast urease test on gastric biopsy specimens was done in all the cases. Bile was sampled during routine ERCP. The final diagnosis was established by surgery, pathohistology, and/or long term clinical follow-up. DNA was extracted for nested PCR for H.p. urease A gene producing a 258 bp product. Result Bile duct malignancies were detected in 15/89 patients (16.8%). H.p was detected in bile by PCR in 12/15 patients (80%), and all of them were H.p. positive on fast urease test. In the remaining 74 patients (bile calculosis 48, cholangitis 17, miscellaneous 9) PCR detected H.p. in 36 patients (48.6%). The group of patient with biliary malignancies had approximately the same ratio smokers/nonsmokers as in the group of patients with other biliary pathology. However, when the patients with PCR for H.p. in bile were excluded, and the group stratified according to the duration and daily quantity of smoking, the group with tumors was made up by heavy, long term smokers (41.7%;>20 pack years) in comparison to the benign condition (13.85%). The duration of coffee consumption was without difference between the analyzed groups (approx. 30 years), but concerning the daily quantity of coffee, the group with biliary malignancies consumed larger amounts (>3 cup/day), in comparison to the other (66.7% vs 30.5 %, respectively). Conclusion There seems to be a strong link between bile duct malignancies and H.p. in bile. The conjuctional effect of smoking to biliary malignancies is based on both long duration and daily quantity, while the coffee consumption has a influence in term of daily amounts rather than duration.
- Subjects
HELICOBACTER pylori; BILE duct diseases; PHYSIOLOGICAL effects of tobacco
- Publication
Journal of Gastroenterology & Hepatology, 2000, Vol 15, Issue 12, pH4
- ISSN
0815-9319
- Publication type
Article
- DOI
10.1046/j.1440-1746.2000.00a14.x