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- Title
Temporal changes of soluble ST2 after cardiovascular interventions.
- Authors
Willems, Sanne; Sels, Jan‐Willem; Flier, Suzanne; Versteeg, Dik; Buhre, Wolfgang F.; Kleijn, Dominique P.V.; Hoefer, Imo E.; Pasterkamp, Gerard
- Abstract
Background Soluble ST2 (s ST2), a member of the IL-1 receptor family, has been proposed as a novel biomarker with predictive value for heart failure and mortality in patients suffering from cardiovascular diseases. The influence of clinical characteristics on variability of s ST2 levels is relatively unexplored. Here, we studied the effect of cardiovascular interventions and clinical characteristics on plasma s ST2 expression levels. Material and methods In the current study, s ST2 levels were assessed in the plasma of patients scheduled for coronary artery bypass grafting ( CABG) ( n = 76), percutaneous coronary intervention ( PCI) ( n = 68) or peripheral vascular surgery ( n = 27). Results Age was the only classical risk factor significantly correlating with s ST2 levels. Soluble ST2 levels were significantly increased 1 h after CABG (48 [33-70] vs. 61 [42-89] pg/mL, P = 0·001) and increased even further after 24 h (1116 [578-13 666] pg/mL, P < 0·001). An average threefold increase in s ST2 levels was also observed in patients 24 h after peripheral interventions (30 [21-41] vs. 98 [48-211] pg/mL, P < 0·001). Two months after PCI, we found that s ST2 levels were significantly higher compared with baseline levels (41 [29-61] vs. 48 [31-80] pg/mL, P = 0·007, n = 52). In addition, we did not observe an association between s ST2 and any inflammatory or cardiac-specific markers that were measured in this study. Conclusions Soluble ST2 increases significantly following cardiovascular interventions. The notion of a recent cardiovascular intervention is a strong determinant of s ST2 levels and therefore needs to be taken into account when exploring s ST2 as predictor of future cardiovascular events.
- Subjects
CARDIOVASCULAR diseases; HEART failure; MORTALITY; CORONARY artery bypass; VASCULAR surgery; MEDICAL research
- Publication
European Journal of Clinical Investigation, 2013, Vol 43, Issue 2, p113
- ISSN
0014-2972
- Publication type
Article
- DOI
10.1111/eci.12022