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- Title
Apolipoprotein E polymorphism and lithogenic factors in gallbladder bile.
- Authors
Fischer, S.; Dolu, M. H.; Zündt, B.; Meyer, G.; Geisler, S.; Jüngst, D.
- Abstract
BackgroundAssociations between the polymorphism of apolipoprotein E, which plays an important role in cholesterol metabolism and cholesterol gallstone formation, have been reported recently. Patients with the apo E4 isoform showed increased numbers and cholesterol contents of their stones, a higher frequency of cholesterol crystals in bile, increased susceptibility to gallstone fragmentation by extracorporeal shock-wave lithotripsy and an increase in recurrence rate after dissolution. A recent study, however, showed that fast cholesterol crystallization in bile is associated with multiple stones but not with apo E4. Therefore the mechanism for an increased risk of gallstone formation in patients with the apo E4 isoform still remains under debate. DesignTo clarify this issue we investigated 37 patients with gallstones (10 with the apo E4 allele and 27 without the allele). Gallbladder biles were examined for total cholesterol and other lipids, cholesterol saturation index, crystal observation time, crystal mass, total protein and mucin. Moreover, number of gallstones and cholesterol in gallstones was compared in both groups. ResultsThe crystal observation time (2·5 vs. 2·0 days, median) and the cholesterol saturation index (1·34 ± 0·45 vs. 1·43 ± 0·74) did not differ significantly between the apo E4 and the non apo E4 group. Total biliary lipids (11·6 ± 3·8 vs. 9·3 ± 3·9 g 100 mL-1, P = 0·126) and total biliary cholesterol (21·8 ± 9·7 vs. 15·7 ± 7 mmol L-1, P = 0·067) tended to be elevated in the apo E4 group. Crystal mass (3·60 ± 4·10 vs. 2·38 ± 2·70 mmol L-1), biliary total protein (8·6 ± 3·5 vs. 8·3 ± 6·6 mg mL-1) and mucin (0·55 ± 0·38 vs. 0·66 ± 0·67 mg mL-1), number (solitary/multiple) of gallstones and...
- Subjects
CHOLESTEROL; GALLSTONES; MUCINS
- Publication
European Journal of Clinical Investigation, 2001, Vol 31, Issue 9, p789
- ISSN
0014-2972
- Publication type
Article
- DOI
10.1046/j.1365-2362.2001.00874.x