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Development of a pediatric physiologically-based pharmacokinetic model to support recommended dosing of atezolizumab in children with solid tumors.
Published in:
Frontiers in Pharmacology, 2022, v. 13, p. 01, doi. 10.3389/fphar.2022.974423
By:
- Weize Huang;
- Stader, Felix;
- Chan, Phyllis;
- Shemesh, Colby S.;
- Yuan Chen;
- Gill, Katherine L.;
- Jones, Hannah M.;
- Linzhong Li;
- Rossato, Gianluca;
- Wu, Benjamin;
- Jin Y. Jin;
- Chanu, Pascal
Publication type:
Article
Physiologically Based Pharmacokinetic Model Development and Verification for Bioequivalence Testing of Bempedoic Acid Oral Suspension and Reference Tablet Formulation.
Published in:
Pharmaceutics, 2023, v. 15, n. 5, p. 1476, doi. 10.3390/pharmaceutics15051476
By:
- Amore, Benny M.;
- Patel, Nikunjkumar;
- Batheja, Priya;
- Templeton, Ian E.;
- Jones, Hannah M.;
- Louie, Michael J.;
- Emery, Maurice G.
Publication type:
Article
Opportunities and Challenges for PBPK Model of mAbs in Paediatrics and Pregnancy.
Published in:
AAPS Journal, 2022, v. 24, n. 4, p. 1, doi. 10.1208/s12248-022-00722-0
By:
- Gill, Katherine L.;
- Jones, Hannah M.
Publication type:
Article
Dose Selection Based on Physiologically Based Pharmacokinetic (PBPK) Approaches.
Published in:
AAPS Journal, 2013, v. 15, n. 2, p. 377, doi. 10.1208/s12248-012-9446-2
By:
- Jones, Hannah M.;
- Mayawala, Kapil;
- Poulin, Patrick
Publication type:
Article
Use of modelling and simulation techniques to support decision making on the progression of PF-04878691, a TLR7 agonist being developed for hepatitis C.
Published in:
British Journal of Clinical Pharmacology, 2012, v. 73, n. 1, p. 77, doi. 10.1111/j.1365-2125.2011.04047.x
By:
- Jones, Hannah M.;
- Chan, Phylinda L. S.;
- van der Graaf, Piet H.;
- Webster, Robert
Publication type:
Article
Using facial muscular movements to understand young children's emotion regulation and concurrent neural activation.
Published in:
Developmental Science, 2018, v. 21, n. 5, p. 1, doi. 10.1111/desc.12628
By:
- Grabell, Adam S.;
- Huppert, Theodore J.;
- Fishburn, Frank A.;
- Li, Yanwei;
- Jones, Hannah M.;
- Wilett, Aimee E.;
- Bemis, Lisa M.;
- Perlman, Susan B.
Publication type:
Article
Creation of Novel Sensitive Probe Substrate and Moderate Inhibitor Models for a Comprehensive Prediction of CYP2C8 Interactions for Tucatinib.
Published in:
Clinical Pharmacology & Therapeutics, 2024, v. 115, n. 2, p. 299, doi. 10.1002/cpt.3104
By:
- Templeton, Ian E.;
- Rowland‐Yeo, Karen;
- Jones, Hannah M.;
- Endres, Christopher J.;
- Topletz‐Erickson, Ariel R.;
- Sun, Hao;
- Lee, Anthony J.
Publication type:
Article
Impact of Disease on Plasma and Lung Exposure of Chloroquine, Hydroxychloroquine and Azithromycin: Application of PBPK Modeling.
Published in:
Clinical Pharmacology & Therapeutics, 2020, v. 108, n. 5, p. 976, doi. 10.1002/cpt.1955
By:
- Rowland Yeo, Karen;
- Zhang, Mian;
- Pan, Xian;
- Ban Ke, Alice;
- Jones, Hannah M.;
- Wesche, David;
- Almond, Lisa M.
Publication type:
Article
The effects of CYP3A4 inhibition on erlotinib pharmacokinetics: computer-based simulation (SimCYP™) predicts in vivo metabolic inhibition.
Published in:
European Journal of Clinical Pharmacology, 2008, v. 64, n. 1, p. 31, doi. 10.1007/s00228-007-0396-z
By:
- Rakhit, Ashok;
- Pantze, Michael P.;
- Fettner, Scott;
- Jones, Hannah M.;
- Charoin, Jean-Eric;
- Riek, Myriam;
- Lum, Bert L.;
- Hamilton, Marta
Publication type:
Article
Physiologically‐based pharmacokinetic modeling of the drug–drug interaction between ivacaftor and lefamulin in cystic fibrosis patients.
Published in:
CPT: Pharmacometrics & Systems Pharmacology, 2024, v. 13, n. 4, p. 589, doi. 10.1002/psp4.13103
By:
- Amiel, Magali;
- Ke, Alice;
- Gelone, Steven P.;
- Jones, Hannah M.;
- Wicha, Wolfgang
Publication type:
Article
A comprehensive evaluation in clinic and physiologically‐based pharmacokinetic modeling and simulation to confirm lack of cytochrome P450–mediated drug–drug interaction potential for pomotrelvir.
Published in:
CPT: Pharmacometrics & Systems Pharmacology, 2023, v. 12, n. 10, p. 1553, doi. 10.1002/psp4.13034
By:
- Yang, Ziping;
- Rioux, Nathalie;
- Vincent, Ludwig;
- Jones, Hannah M.;
- Cha, David;
- Plummer, Andrew;
- Wilfret, David;
- Kearney, Brian P.
Publication type:
Article
Development and application of a PBPK modeling strategy to support antimalarial drug development.
Published in:
CPT: Pharmacometrics & Systems Pharmacology, 2023, v. 12, n. 9, p. 1335, doi. 10.1002/psp4.13013
By:
- Abla, Nada;
- Howgate, Eleanor;
- Rowland‐Yeo, Karen;
- Dickins, Maurice;
- Bergagnini‐Kolev, Mackenzie C.;
- Chen, Kuan‐Fu;
- McFeely, Savannah;
- Bonner, Jennifer J.;
- Santos, Laura G. A.;
- Gobeau, Nathalie;
- Burt, Howard;
- Barter, Zoe;
- Jones, Hannah M.;
- Wesche, David;
- Charman, Susan A.;
- Möhrle, Jörg J.;
- Burrows, Jeremy N.;
- Almond, Lisa M.
Publication type:
Article
Tiered approach to evaluate the CYP3A victim and perpetrator drug–drug interaction potential for vonoprazan using PBPK modeling and clinical data to inform labeling.
Published in:
CPT: Pharmacometrics & Systems Pharmacology, 2023, v. 12, n. 4, p. 532, doi. 10.1002/psp4.12939
By:
- Mulford, Darcy J.;
- Ramsden, Diane;
- Zhang, Liming;
- Michon, Ingrid;
- Leifke, Eckhard;
- Smith, Neila;
- Jones, Hannah M.;
- Scarpignato, Carmelo
Publication type:
Article
PBPK perspective on alternative CYP3A4 inducers for rifampin.
Published in:
CPT: Pharmacometrics & Systems Pharmacology, 2022, v. 11, n. 12, p. 1543, doi. 10.1002/psp4.12864
By:
- Chen, Kuan‐Fu;
- Jones, Hannah M.
Publication type:
Article
A Physiologically‐Based Pharmacokinetic Model for the Prediction of "Half‐Life Extension" and "Catch and Release" Monoclonal Antibody Pharmacokinetics.
Published in:
CPT: Pharmacometrics & Systems Pharmacology, 2020, v. 9, n. 9, p. 534, doi. 10.1002/psp4.12547
By:
- Jones, Hannah M.;
- Tolsma, John;
- Zhang, Zhiwei;
- Jasper, Paul;
- Luo, Haobin;
- Weber, Gregory L.;
- Wright, Katherine;
- Bard, Joel;
- Bell, Robert;
- Messing, Dean;
- Kelleher, Kerry;
- Piche‐Nicholas, Nicole;
- Webster, Robert
Publication type:
Article
A Physiologically‐Based Pharmacokinetic Model for the Prediction of Monoclonal Antibody Pharmacokinetics From In Vitro Data.
Published in:
CPT: Pharmacometrics & Systems Pharmacology, 2019, v. 8, n. 10, p. 738, doi. 10.1002/psp4.12461
By:
- Jones, Hannah M.;
- Zhang, Zhiwei;
- Jasper, Paul;
- Luo, Haobin;
- Avery, Lindsay B.;
- King, Lindsay E.;
- Neubert, Hendrik;
- Barton, Hugh A.;
- Betts, Alison M.;
- Webster, Robert
Publication type:
Article
Clinical Micro-Dose Studies to Explore the Human Pharmacokinetics of Four Selective Inhibitors of Human Nav1.7 Voltage-Dependent Sodium Channels.
Published in:
2016
By:
- Jones, Hannah;
- Butt, Richard;
- Webster, Rob;
- Gurrell, Ian;
- Dzygiel, Pawel;
- Flanagan, Neil;
- Fraier, Daniela;
- Hay, Tanya;
- Iavarone, Laura;
- Luckwell, Jacquelynn;
- Pearce, Hannah;
- Phipps, Alex;
- Segelbacher, Jill;
- Speed, Bill;
- Beaumont, Kevin;
- Jones, Hannah M;
- Butt, Richard P;
- Webster, Rob W;
- Iavarone, Laura Else
Publication type:
journal article
Predicting pharmacokinetic food effects using biorelevant solubility media and physiologically based modelling.
Published in:
2006
By:
- Jones, Hannah M.;
- Parrott, Neil;
- Ohlenbusch, Gerd;
- Lavé, Thierry;
- Lavé, Thierry
Publication type:
journal article
A novel strategy for physiologically based predictions of human pharmacokinetics.
Published in:
2006
By:
- Jones, Hannah M.;
- Parrott, Neil;
- Jorga, Karin;
- Lavé, Thierry;
- Lavé, Thierry
Publication type:
journal article
Cure4Kids: Two decades of knowledge transfer.
Published in:
Pediatric Blood & Cancer, 2022, v. 69, n. 12, p. 1, doi. 10.1002/pbc.30007
By:
- Moreira, Daniel C.;
- Jones, Hannah M.;
- Schaeffer, Elizabeth;
- Wellman, Andrew;
- Shuler, Ana;
- Ribeiro, Raul;
- Chantada, Guillermo;
- Rodriguez‐Galindo, Carlos
Publication type:
Article
Evaluation of the antitumor effects of c-Myc-Max heterodimerization inhibitor 100258-F4 in ovarian cancer cells.
Published in:
Journal of Translational Medicine, 2014, v. 12, n. 1, p. 1, doi. 10.1186/s12967-014-0226-x
By:
- Jiandong Wang;
- Xiaoli Ma;
- Jones, Hannah M.;
- Leo Li-Ying Chan;
- Fang Song;
- Weiyuan Zhang;
- Bae-Jump, Victoria L.;
- Chunxiao Zhou
Publication type:
Article
Evaluation of the antitumor effects of c-Myc-Max heterodimerization inhibitor 100258-F4 in ovarian cancer cells.
Published in:
2014
By:
- Wang, Jiandong;
- Ma, Xiaoli;
- Jones, Hannah M;
- Chan, Leo Li-Ying;
- Song, Fang;
- Zhang, Weiyuan;
- Bae-Jump, Victoria L;
- Zhou, Chunxiao
Publication type:
journal article
Evaluation of the anti-tumor effects of lactate dehydrogenase inhibitor galloflavin in endometrial cancer cells.
Published in:
Journal of Hematology & Oncology, 2015, v. 8, n. 1, p. 1, doi. 10.1186/s13045-014-0097-x
By:
- Xiaoyun Han;
- Xiugui Sheng;
- Jones, Hannah M.;
- Jackson, Amanda L.;
- Kilgore, Joshua;
- Stine, Jessica E.;
- Schointuch, Monica N.;
- Chunxiao Zhou;
- Bae-Jump, Victoria L.
Publication type:
Article
Evaluation of the anti-tumor effects of lactate dehydrogenase inhibitor galloflavin in endometrial cancer cells.
Published in:
Journal of Hematology & Oncology, 2015, v. 8, n. 1, p. 1, doi. 10.1186/s13045-014-0097-x
By:
- Xiaoyun Han;
- Xiugui Sheng;
- Jones, Hannah M.;
- Jackson, Amanda L.;
- Kilgore, Joshua;
- Stine, Jessica E.;
- Schointuch, Monica N.;
- Chunxiao Zhou;
- Bae-Jump, Victoria L.
Publication type:
Article
Estimation of brain receptor occupancy for trazodone immediate release and once a day formulations.
Published in:
CTS: Clinical & Translational Science, 2022, v. 15, n. 6, p. 1417, doi. 10.1111/cts.13253
By:
- Oggianu, Laura;
- Di Dato, Giorgio;
- Mangano, Giorgina;
- Rosignoli, Maria Teresa;
- McFeely, Savannah;
- Ke, Alice Ban;
- Jones, Hannah M.;
- Comandini, Alessandro
Publication type:
Article
Fast-Acting Insulin Aspart Versus Insulin Aspart Using a Second-Generation Hybrid Closed-Loop System in Adults With Type 1 Diabetes: A Randomized, Open-Label, Crossover Trial.
Published in:
2021
By:
- Lee, Melissa H.;
- Paldus, Barbora;
- Vogrin, Sara;
- Morrison, Dale;
- Zaharieva, Dessi P.;
- Lu, Jean;
- Jones, Hannah M.;
- Netzer, Emma;
- Robinson, Lesley;
- Grosman, Benyamin;
- Roy, Anirban;
- Kurtz, Natalie;
- Ward, Glenn M.;
- Maclsaac, Richard J.;
- Jenkins, Alicia J.;
- O'Neal, David N.;
- MacIsaac, Richard J
Publication type:
journal article
Glucose and Counterregulatory Responses to Exercise in Adults With Type 1 Diabetes and Impaired Awareness of Hypoglycemia Using Closed-Loop Insulin Delivery: A Randomized Crossover Study.
Published in:
2020
By:
- Lee, Melissa H.;
- Vogrin, Sara;
- Paldus, Barbora;
- Jayawardene, Dilshani;
- Jones, Hannah M.;
- McAuley, Sybil A.;
- Obeyesekere, Varuni;
- Gooley, Judith;
- La Gerche, André;
- MacIsaac, Richard J.;
- Sundararajan, Vijaya;
- Jenkins, Alicia J.;
- Ward, Glenn M.;
- O'Neal, David N.
Publication type:
journal article

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