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Cost-effectiveness of monitoring endoxifen levels in breast cancer patients adjuvantly treated with tamoxifen.
Published in:
Breast Cancer Research & Treatment, 2018, v. 172, n. 1, p. 143, doi. 10.1007/s10549-018-4886-8
By:
- van Nuland, M.;
- Vreman, R. A.;
- ten Ham, R. M. T.;
- de Vries Schultink, A. H. M.;
- Rosing, H.;
- Schellens, J. H. M.;
- Beijnen, J. H.;
- Hövels, A. M.
Publication type:
Article
Propofol extravasation in a breast cancer patient.
Published in:
2008
By:
- Huijbers, E. J. M.;
- Baars, J. W.;
- Schutte, P. F. E.;
- Schellens, J. H. M.;
- Beijnen, J. H.
Publication type:
Case Study
Inductively coupled plasma mass spectrometric analysis of the total amount of platinum in DNA extracts from peripheral blood mononuclear cells and tissue from patients treated with cisplatin.
Published in:
Analytical & Bioanalytical Chemistry, 2008, v. 391, n. 2, p. 577, doi. 10.1007/s00216-008-2034-8
By:
- Brouwers, E. E. M.;
- Tibben, M. M.;
- Pluim, D.;
- Rosing, H.;
- Boot, H.;
- Cats, A.;
- Schellens, J. H. M.;
- Beijnen, J. H.
Publication type:
Article
Determination of oxaliplatin in human plasma and plasma ultrafiltrate by graphite-furnace atomic-absorption spectrometry.
Published in:
Analytical & Bioanalytical Chemistry, 2005, v. 382, n. 7, p. 1484, doi. 10.1007/s00216-005-3302-5
By:
- Brouwers, E. E. M.;
- Tibben, M. M.;
- Joerger, M.;
- Van Tellingen, O.;
- Rosing, H.;
- Schellens, J. H. M.;
- Beijnen, J. H.
Publication type:
Article
Quantitative analysis of gemcitabine triphosphate in human peripheral blood mononuclear cells using weak anion-exchange liquid chromatography coupled with tandem mass spectrometry.
Published in:
Journal of Mass Spectrometry, 2006, v. 41, n. 12, p. 1633, doi. 10.1002/jms.1133
By:
- Veltkamp, S. A.;
- Hillebrand, M. J. X.;
- Rosing, H.;
- Jansen, R. S.;
- Wickremsinhe, E. R.;
- Perkins, E. J.;
- Schellens, J. H. M.;
- Beijnen, J. H.
Publication type:
Article
Sensitive inductively coupled plasma mass spectrometry assay for the determination of platinum originating from cisplatin, carboplatin, and oxaliplatin in human plasma ultrafiltrate.
Published in:
Journal of Mass Spectrometry, 2006, v. 41, n. 9, p. 1186, doi. 10.1002/jms.1087
By:
- Brouwers, E. E. M.;
- Tibben, M. M.;
- Rosing, H.;
- Hillebrand, M. J. X.;
- Joerger, M.;
- Schellens, J. H. M.;
- Beijnen, J. H.
Publication type:
Article
Quantitative analysis of ES-285, an investigational marine anticancer drug, in human, mouse, rat, and dog plasma using coupled liquid chromatography and tandem mass spectrometry.
Published in:
Journal of Mass Spectrometry, 2003, v. 38, n. 5, p. 548, doi. 10.1002/jms.469
By:
- Stokvis, E.;
- Nan-Offeringa, L.;
- Rosing, H.;
- López-Lázaro, L.;
- Aceña, J. L.;
- Miranda, E.;
- Lyubimov, A.;
- Levine, B. S.;
- D'Aleo, C.;
- Schellens, J. H. M.;
- Beijnen, J. H.
Publication type:
Article
Population Pharmacokinetic-Pharmacodynamic Analysis of Trastuzumab-Associated Cardiotoxicity.
Published in:
Clinical Pharmacology & Therapeutics, 2011, v. 90, n. 1, p. 126, doi. 10.1038/clpt.2011.74
By:
- van Hasselt, J. G. C.;
- Boekhout, A. H.;
- Beijnen, J. H.;
- Schellens, J. H. M.;
- Huitema, A. D. R.
Publication type:
Article
Intravenous-to-Oral Switch in Anticancer Chemotherapy: A Focus on Docetaxel and Paclitaxel.
Published in:
Clinical Pharmacology & Therapeutics, 2010, v. 87, n. 1, p. 126, doi. 10.1038/clpt.2009.233
By:
- Koolen, S. L. W.;
- Beijnen, J. H.;
- Schellens, J. H. M.
Publication type:
Article
The Dutch Vision of Clinical Pharmacology.
Published in:
Clinical Pharmacology & Therapeutics, 2009, v. 85, n. 4, p. 366, doi. 10.1038/clpt.2008.148
By:
- Schellens, J. H. M.;
- Grouls, R.;
- Guchelaar, H. J.;
- Touw, D. J.;
- Rongen, G. A.;
- de Boer, A.;
- Van Bortel, L. M.
Publication type:
Article
Novel Clinical Trial Designs for Innovative Therapies.
Published in:
Clinical Pharmacology & Therapeutics, 2009, v. 85, n. 2, p. 212, doi. 10.1038/clpt.2008.247
By:
- Schellens, J. H. M.;
- Beijnen, J. H.
Publication type:
Article
PK/PD Model of Indisulam and Capecitabine: Interaction Causes Excessive Myelosuppression.
Published in:
Clinical Pharmacology & Therapeutics, 2008, v. 83, n. 6, p. 829, doi. 10.1038/sj.clpt.6100344
By:
- Zandvliet, A. S.;
- Siegel-Lakhai, W. S.;
- Beijnen, J. H.;
- Copalu, W.;
- Etienne-Grimaldi, M.-C.;
- Milano, G.;
- Schellens, J. H. M.;
- Huitema, A. D. R.
Publication type:
Article
Quantification of docetaxel and its metabolites in human plasma by liquid chromatography/tandem mass spectrometry.
Published in:
Rapid Communications in Mass Spectrometry: RCM, 2013, v. 27, n. 17, p. 1925, doi. 10.1002/rcm.6654
By:
- Hendrikx, J. J. M. A.;
- Dubbelman, A. C.;
- Rosing, H.;
- Schinkel, A. H.;
- Schellens, J. H. M.;
- Beijnen, J. H.
Publication type:
Article
Phase I dose-finding and pharmacokinetic trial of orally administered indibulin (D-24851) to patients with solid tumors.
Published in:
Investigational New Drugs, 2007, v. 25, n. 3, p. 227, doi. 10.1007/s10637-006-9027-2
By:
- Kuppens, I. E. L. M.;
- Witteveen, P. O.;
- Schot, M.;
- Schuessler, V. M.;
- Daehling, A.;
- Beijnen, J. H.;
- Voest, E. E.;
- Schellens, J. H. M.
Publication type:
Article
Trabectedin (YondelisTM, formerly ET-743), a mass balance study in patients with advanced cancer.
Published in:
Investigational New Drugs, 2005, v. 23, n. 5, p. 429, doi. 10.1007/s10637-005-2902-4
By:
- J. H. Beumer;
- J. M. Rademaker-Lakhai;
- H. Rosing;
- L. Lopez-Lazaro;
- J. H. Beijnen;
- J. H. M. Schellens
Publication type:
Article
Switching from an analogous to a stable isotopically labeled internal standard for the LC-MS/MS quantitation of the novel anticancer drug Kahalalide F significantly improves assay performance.
Published in:
Biomedical Chromatography, 2004, v. 18, n. 6, p. 400, doi. 10.1002/bmc.392
By:
- Stokvis, E.;
- Rosing, H.;
- López-Lázaro, L.;
- Schellens, J. H. M.;
- Beijnen, J. H.
Publication type:
Article
Ciprofloxacin Strongly Inhibits Clozapine Metabolism: Two Case Reports.
Published in:
Clinical Drug Investigation, 2009, v. 29, n. 1, p. 59, doi. 10.2165/0044011-200929010-00006
By:
- Brouwers, E. E. M.;
- M. Söhne;
- Kuipers, S.;
- van Gorp, E. C. M.;
- Schellens, J. H. M.;
- Koks, C. H. W.;
- Beijnen, J. H.;
- Huitema, A. D. R.
Publication type:
Article
Pharmacogenetic Screening for Polymorphisms in Drug-Metabolizing Enzymes and Drug Transporters in a Dutch Population.
Published in:
Molecular Diagnosis & Therapy, 2006, v. 10, n. 3, p. 175, doi. 10.1007/BF03256456
By:
- Bosch, T. M.;
- Doodeman, V. D.;
- Smits, P. H. M.;
- Meijerman, I.;
- Schellens, J. H. M.;
- Beijnen, J. H.
Publication type:
Article
Phase I and pharmacological study of pazopanib in combination with oral topotecan in patients with advanced solid tumours.
Published in:
British Journal of Cancer, 2015, v. 113, n. 5, p. 706, doi. 10.1038/bjc.2015.257
By:
- Kerklaan, B Milojkovic;
- Lolkema, M P J;
- Devriese, L A;
- Voest, E E;
- Nol-Boekel, A;
- Mergui-Roelvink, M;
- Langenberg, M;
- Mykulowycz, K;
- Stoebenau, J;
- Lane, S;
- Legenne, P;
- Wissel, P;
- Smith, D A;
- Giantonio, B J;
- Schellens, J H M;
- Witteveen, P O
Publication type:
Article
HPV-negative squamous cell carcinoma of the anal canal is unresponsive to standard treatment and frequently carries disruptive mutations in TP53.
Published in:
British Journal of Cancer, 2015, v. 112, n. 8, p. 1358, doi. 10.1038/bjc.2015.20
By:
- Meulendijks, D;
- Tomasoa, N B;
- Dewit, L;
- Smits, P H M;
- Bakker, R;
- van Velthuysen, M-L F;
- Rosenberg, E H;
- Beijnen, J H;
- Schellens, J H M;
- Cats, A
Publication type:
Article
Chemoradiotherapy with capecitabine for locally advanced anal carcinoma: an alternative treatment option.
Published in:
British Journal of Cancer, 2014, v. 111, n. 9, p. 1726, doi. 10.1038/bjc.2014.467
By:
- Meulendijks, D;
- Dewit, L;
- Tomasoa, N B;
- van Tinteren, H;
- Beijnen, J H;
- Schellens, J H M;
- Cats, A
Publication type:
Article
Pharmacokinetically guided sunitinib dosing: a feasibility study in patients with advanced solid tumours.
Published in:
British Journal of Cancer, 2014, v. 110, n. 10, p. 2441, doi. 10.1038/bjc.2014.194
By:
- Lankheet, N A G;
- Kloth, J S L;
- Gadellaa-van Hooijdonk, C G M;
- Cirkel, G A;
- Mathijssen, R H J;
- Lolkema, M P J K;
- Schellens, J H M;
- Voest, E E;
- Sleijfer, S;
- de Jonge, M J A;
- Haanen, J B A G;
- Beijnen, J H;
- Huitema, A D R;
- Steeghs, N
Publication type:
Article
Oral co-administration of elacridar and ritonavir enhances plasma levels of oral paclitaxel and docetaxel without affecting relative brain accumulation.
Published in:
British Journal of Cancer, 2014, v. 110, n. 11, p. 2669, doi. 10.1038/bjc.2014.222
By:
- Hendrikx, J J M A;
- Lagas, J S;
- Wagenaar, E;
- Rosing, H;
- Schellens, J H M;
- Beijnen, J H;
- Schinkel, A H
Publication type:
Article
A phase I study of E7080, a multitargeted tyrosine kinase inhibitor, in patients with advanced solid tumours.
Published in:
British Journal of Cancer, 2012, v. 106, n. 10, p. 1598, doi. 10.1038/bjc.2012.154
By:
- Boss, D S;
- Glen, H;
- Beijnen, J H;
- Keesen, M;
- Morrison, R;
- Tait, B;
- Copalu, W;
- Mazur, A;
- Wanders, J;
- O'Brien, J P;
- Schellens, J H M;
- Evans, T R J
Publication type:
Article
A multimarker QPCR-based platform for the detection of circulating tumour cells in patients with early-stage breast cancer.
Published in:
2011
By:
- Molloy, T. J.;
- Devriese, L. A.;
- Helgason, H. H.;
- Bosma, A. J.;
- Hauptmann, M.;
- Voest, E. E.;
- Schellens, J. H. M.;
- van't Veer, L. J.
Publication type:
journal article
Methotrexate area under the curve is an important outcome predictor in patients with primary CNS lymphoma: A pharmacokinetic-pharmacodynamic analysis from the IELSG no. 20 trial.
Published in:
2010
By:
- Joerger, M.;
- Huitema, A. D. R.;
- Krähenbühl, S.;
- Schellens, J. H. M.;
- Cerny, T.;
- Reni, M.;
- Zucca, E.;
- Cavalli, F.;
- Ferreri, A. J. M.;
- Krähenbühl, S
Publication type:
journal article
Herb-Drug Interactions in Oncology.
Published in:
Clinical Pharmacology & Therapeutics, 2014, v. 95, n. 4, p. 354, doi. 10.1038/clpt.2014.18
By:
- Goey, A K L;
- Beijnen, J H;
- Schellens, J H M
Publication type:
Article
Study protocols of three parallel phase 1 trials combining radical radiotherapy with the PARP inhibitor olaparib.
Published in:
2019
By:
- de Haan, R.;
- van Werkhoven, E.;
- van den Heuvel, M.M.;
- Peulen, H. M. U.;
- Sonke, G. S.;
- Elkhuizen, P.;
- van den Brekel, M. W. M.;
- Tesselaar, M. E. T.;
- Vens, C.;
- Schellens, J. H. M.;
- van Triest, B.;
- Verheij, M.
Publication type:
journal article
Development and validation of a liquid chromatography–tandem mass spectrometry analytical method for the therapeutic drug monitoring of eight novel anticancer drugs.
Published in:
Biomedical Chromatography, 2018, v. 32, n. 4, p. 1, doi. 10.1002/bmc.4147
By:
- Herbrink, M.;
- de Vries, N.;
- Rosing, H.;
- Huitema, A. D. R.;
- Nuijen, B.;
- Schellens, J. H. M.;
- Beijnen, J. H.
Publication type:
Article
Development and validation of a LC-MS/MS method for the in vitro analysis of 1-hydroxymidazolam in human liver microsomes: application for determining CYP3A4 inhibition in complex matrix mixtures.
Published in:
Biomedical Chromatography, 2013, v. 27, n. 9, p. 1107, doi. 10.1002/bmc.2913
By:
- Mooiman, K. D.;
- Maas‐Bakker, R. F.;
- Rosing, H.;
- Beijnen, J. H.;
- Schellens, J. H. M.;
- Meijerman, I.
Publication type:
Article
Method development and validation for the quantification of dasatinib, erlotinib, gefitinib, imatinib, lapatinib, nilotinib, sorafenib and sunitinib in human plasma by liquid chromatography coupled with tandem mass spectrometry.
Published in:
Biomedical Chromatography, 2013, v. 27, n. 4, p. 466, doi. 10.1002/bmc.2814
By:
- Lankheet, N. A. G.;
- Hillebrand, M. J. X.;
- Rosing, H.;
- Schellens, J. H. M.;
- Beijnen, J. H.;
- Huitema, A. D. R.
Publication type:
Article
Quantitative analysis of docetaxel in human plasma using liquid chromatography coupled with tandem mass spectrometry.
Published in:
Biomedical Chromatography, 2005, v. 19, n. 5, p. 355, doi. 10.1002/bmc.457
By:
- Kuppens, I. E. L. M.;
- van Maanen, M. J.;
- Rosing, H.;
- Schellens, J. H. M.;
- Beijnen, J. H.
Publication type:
Article
Novel deoxycytidine kinase gene polymorphisms: a population screening study in Caucasian healthy volunteers.
Published in:
European Journal of Clinical Pharmacology, 2006, v. 62, n. 8, p. 681, doi. 10.1007/s00228-006-0162-7
By:
- Joerger, M.;
- Bosch, T. M.;
- Doodeman, V. D.;
- Beijnen, J. H.;
- Smits, P. H. M.;
- Schellens, J. H. M.
Publication type:
Article
Pharmacokinetics of oral cyclosporin A when co-administered to enhance the absorption of orally administered docetaxel.
Published in:
European Journal of Clinical Pharmacology, 2001, v. 57, n. 4, p. 305, doi. 10.1007/s002280100315
By:
- Malingré, M. M.;
- Ten Bokkel Huinink, W. W.;
- Mackay, M.;
- Schellens, J. H M.;
- Beijnen, J. H.
Publication type:
Article
Monitoring of EGFR mutations in circulating tumor DNA of non-small cell lung cancer patients treated with EGFR inhibitors.
Published in:
2021
By:
- Verheijen, R. B.;
- van Duijl, T. T.;
- van den Heuvel, M. M.;
- Vessies, D.;
- Muller, M.;
- Beijnen, J. H.;
- Janssen, J. M.;
- Schellens, J. H. M.;
- Steeghs, N.;
- van den Broek, D.;
- Huitema, A. D. R.
Publication type:
journal article
Correction to: Exposure-survival analyses of pazopanib in renal cell carcinoma and soft tissue sarcoma patients: opportunities for dose optimization.
Published in:
2020
By:
- Verheijen, R. B.;
- Swart, E. L.;
- Beijnen, J. H.;
- Schellens, J. H. M.;
- Huitema, A. D. R.;
- Steeghs, N.
Publication type:
Correction Notice
Metabolite profiling of the novel anti-cancer agent, plitidepsin, in urine and faeces in cancer patients after administration of 14C-plitidepsin.
Published in:
2018
By:
- Rosing, H.;
- Tibben, M. M.;
- Lucas, L.;
- Gebretensae, A.;
- Hillebrand, M. J. X.;
- van Andel, L.;
- Beijnen, J. H.;
- Schellens, J. H. M.;
- Lubomirov, R.;
- Avilés, P.;
- Francesch, A.;
- Fudio, S.
Publication type:
journal article
Determination of the absolute oral bioavailability of niraparib by simultaneous administration of a 14C-microtracer and therapeutic dose in cancer patients.
Published in:
2018
By:
- van Andel, L.;
- Rosing, H.;
- Zhang, Z.;
- Hughes, L.;
- Kansra, V.;
- Sanghvi, M.;
- Tibben, M. M.;
- Gebretensae, A.;
- Schellens, J. H. M.;
- Beijnen, J. H.
Publication type:
journal article
Correction to: Determination of the absolute oral bioavailability of niraparib by simultaneous administration of a 14C-microtracer and therapeutic dose in cancer patients.
Published in:
2018
By:
- van Andel, L.;
- Rosing, H.;
- Zhang, Z.;
- Hughes, L.;
- Kansra, V.;
- Sanghvi, M.;
- Tibben, M. M.;
- Gebretensae, A.;
- Schellens, J. H. M.;
- Beijnen, J. H.
Publication type:
journal article
Exposure-survival analyses of pazopanib in renal cell carcinoma and soft tissue sarcoma patients: opportunities for dose optimization.
Published in:
2017
By:
- Verheijen, R.;
- Swart, L.;
- Beijnen, J.;
- Schellens, J.;
- Huitema, A.;
- Steeghs, N.;
- Verheijen, R B;
- Swart, L E;
- Beijnen, J H;
- Schellens, J H M;
- Huitema, A D R
Publication type:
journal article
PXR-mediated induction of P-glycoprotein by anticancer drugs in a human colon adenocarcinoma-derived cell line.
Published in:
2010
By:
- Harmsen S;
- Meijerman I;
- Febus CL;
- Maas-Bakker RF;
- Beijnen JH;
- Schellens JH;
- Harmsen, Stefan;
- Meijerman, I;
- Febus, C L;
- Maas-Bakker, R F;
- Beijnen, J H;
- Schellens, J H M
Publication type:
journal article
PXR-mediated induction of P-glycoprotein by anticancer drugs in a human colon adenocarcinoma-derived cell line.
Published in:
Cancer Chemotherapy & Pharmacology, 2010, v. 66, n. 4, p. 765, doi. 10.1007/s00280-009-1221-4
By:
- Harmsen, Stefan;
- Meijerman, I.;
- Febus, C. L.;
- Maas-Bakker, R. F.;
- Beijnen, J. H.;
- Schellens, J. H. M.
Publication type:
Article
Nuclear receptor mediated induction of cytochrome P450 3A4 by anticancer drugs: a key role for the pregnane X receptor.
Published in:
Cancer Chemotherapy & Pharmacology, 2009, v. 64, n. 1, p. 35, doi. 10.1007/s00280-008-0842-3
By:
- Harmsen, S.;
- Meijerman, I.;
- Beijnen, J. H.;
- Schellens, J. H. M.
Publication type:
Article
Cisplatin-DNA adduct formation in patients treated with cisplatin-based chemoradiation: lack of correlation between normal tissues and primary tumor.
Published in:
Cancer Chemotherapy & Pharmacology, 2008, v. 61, n. 6, p. 1075, doi. 10.1007/s00280-007-0545-1
By:
- Hoebers, F. J. P.;
- Pluim, D.;
- Hart, A. A. M.;
- Verheij, M.;
- Balm, A. J. M.;
- Fons, G.;
- Rasch, C. R. N.;
- Schellens, J. H. M.;
- Stalpers, L. J. A.;
- Bartelink, H.;
- Begg, A. C.
Publication type:
Article
A pharmacokinetic and safety study of a novel polymeric paclitaxel formulation for oral application.
Published in:
Cancer Chemotherapy & Pharmacology, 2007, v. 59, n. 1, p. 43, doi. 10.1007/s00280-006-0245-2
By:
- Veltkamp, S. A.;
- Alderden-Los, C.;
- Sharma, A.;
- Rosing, H.;
- Beijnen, J. H.;
- Schellens, J. H. M.
Publication type:
Article
A population analysis of the pharmacokinetics of Cremophor EL using nonlinear mixed-effect modelling.
Published in:
Cancer Chemotherapy & Pharmacology, 2002, v. 50, n. 1, p. 16, doi. 10.1007/s00280-002-0459-x
By:
- van den Bongard, H. J. G. D.;
- Mathôt, R. A. A.;
- van Tellingen, O.;
- Schellens, J. H. M.;
- Beijnen, J. H.
Publication type:
Article
A comparison of limited sampling strategies for prediction of Ecteinascidin 743 clearance when administered as a 24-h infusion.
Published in:
2001
By:
- van Kesteren, Charlotte;
- Math&ocric;t, R. A. A.;
- López-Lázaro, L.;
- Cvitkovic, E.;
- Taamma, A.;
- Jimeno, J. M.;
- Guzman, C.;
- Schellens, J. H. M.;
- Misset, J. L.;
- Brain, E.;
- Hillebrand, M. J. X.;
- Rosing, H.;
- Beijnen, J. H.;
- van Kesteren, C;
- Mathĵt, R A;
- López-Lázaro, L;
- Schellens, J H;
- Hillebrand, M J
Publication type:
journal article
Successful treatment with paclitaxel of a patient with metastatic extra-adrenal pheochromocytoma (paraganglioma) : A case report and review of the literature.
Published in:
Cancer Chemotherapy & Pharmacology, 2000, v. 45, n. 5, p. 428, doi. 10.1007/s002800051013
By:
- Kruijtzer, C. M. F.;
- Beijnen, J. H.;
- Swart, M.;
- Schellens, J. H. M.
Publication type:
Article
Pharmacokinetics and metabolism of docetaxel administered as a 1-h intravenous infusion.
Published in:
2000
By:
- Rosing, H.;
- Lustig, V.;
- Van Warmerdam, L. J. C.;
- Huizing, M. T.;
- Bokkel Huinink, W. W. Ten;
- Schellens, J. H. M.;
- Rodenhuis, S.;
- Bult, A.;
- Beijnen, J. H.;
- van Warmerdam, L J;
- ten Bokkel Huinink, W W;
- Schellens, J H
Publication type:
journal article
Interactions of Serum Albumin, Valproic Acid and Carbamazepine with the Pharmacokinetics of Phenytoin in Cancer Patients.
Published in:
Basic & Clinical Pharmacology & Toxicology, 2006, v. 99, n. 2, p. 133, doi. 10.1111/j.1742-7843.2006.pto_309.x
By:
- Joerger, Markus;
- Huitema, A. D. R.;
- Boogerd, W.;
- van der Sande, J. J.;
- Schellens, J. H. M.;
- Beijnen, J. H.
Publication type:
Article

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