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- Title
Improved Synthesis and Crystal Structure of Dalcetrapib.
- Authors
Laus, Gerhard; Kahlenberg, Volker; Richter, Frank; Nerdinger, Sven; Schottenberger, Herwig
- Abstract
An improved synthesis of the Cholesteryl Ester Transfer Protein inhibitor dalcetrapib is reported. The precursor disulfide was reduced (a) by Mg/MeOH or (b) by EtSH/DBU/THF. The resulting thiol was acylated (a) by a known procedure or (b) in a one-pot process. Impurities were removed (a) by dithiothreitol (DTT) or (b) by oxidation using H2O2. Dalcetrapib crystallized in space group P21/c.
- Subjects
CRYSTAL structure; CHOLESTEROL esters; THIOLS; OXIDATION; THIOESTERS; CRYSTALLOGRAPHY; SPACE groups
- Publication
Crystals (2073-4352), 2012, Vol 2, Issue 4, p1455
- ISSN
2073-4352
- Publication type
Article
- DOI
10.3390/cryst2041455