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- Title
Description of Zoonotic Pseudocowpoxvirus Infection of Cattle in Russia.
- Authors
Sindryakova, Irina; Blokhin, Andrey; Lyska, Valentina; Titov, Ilya
- Abstract
Simple Summary: This work describes a case study of pseudocowpoxvirus (PCPV) infection in Russia (Irkutsk region). The clinical manifestation, molecular identification, and molecular characterization of the disease were established. Epidemiological information were provided by the state veterinary service; additionally, the cows' owners were interviewed using a semi-structured questionnaire. The description of clinical symptoms was based on clinical examination and farmer interviewing. Samples (blood, serum, scab) were collected from the affected cattle for virological studies and molecular analyses. The identification of PCPV was accomplished through the B2L gene fragment amplification, sequencing, and phylogenetic analysis. Based on the nucleotide identities and phylogenetic analysis of the partial-length B2L gene, the Irkutsk 2019 isolate was classified as PCPV. Because of high rates of virus transmission amongst cattle-to-cattle and cattle-to-humans through direct contact, it is important to raise farmers' awareness of the clinical signs of the disease, highlight its preventive measures, and to develop a strategy to motivate them to seek qualified veterinary care. Parapoxviruses are worldwide epitheliotropic viruses that affect ruminants. Viruses of this genus have a narrow host range; however, the pseudocowpox virus (PCPV) also infects humans. Unfortunately, these cases are not well documented, and the epidemiology and the properties of the causative agents are not properly described. Here, we report the first case of PCPV in northern Russia (the Irkutsk region). The infection occurred in non-immune herds where no new arrivals of animals had been reported. Moreover, clinical signs of infection (skin lesions) were observed in humans. Based on the nucleotide identity and phylogenetic analysis of the partial-length B2L gene, the Irkutsk 2019 isolate was classified as PCPV. Phylogenetic analysis based on the nucleotide sequence of the B2L gene fragment of PCPV revealed a close phylogenetic relationship between the Irkutsk 2019 isolate and the PCPV strains isolated in Europe and the USA. The high degree of conservatism of the B2L gene does not allow for finding a correlation between their geographical origin and the results of phylogenetic analysis.
- Subjects
IRKUTSK (Russia); RUSSIA; VETERINARY medicine; CATTLE; SYMPTOMS; GENE amplification; VETERINARY services; MOSAIC viruses
- Publication
Animals (2076-2615), 2024, Vol 14, Issue 6, p969
- ISSN
2076-2615
- Publication type
Article
- DOI
10.3390/ani14060969