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- Title
ANALYSIS OF AMBROXOL HYDROCHLORIDE IN FLAVAMED® TABLETS BY MEANS OF SPECTROSCOPIC ABSORPTION METHODS.
- Authors
JELIĆ, DIJANA; FAZLAGIĆ, SAIDA; ANTUNOVIĆ, VESNA; BUBIĆ-PAJIĆ, NATAŠA; RAČIĆ, ANĐELKA; ĐERMANOVIĆ, MIRJANA
- Abstract
Ambroxol hydrochloride (AMB), (1s,4s)-4-((2-amino-3,5-dibromocyclohexyl)methylamino) cyclohexanol hydrochloride, is semi - synthetic derivative of vasicine obtained from Indian shrub Adhatoda vasica. It is a metabolic product of bromhexin and it is used as broncho secretolytic and an expectorant drug. Analysis of Flavamed® tablets, in which ambroxol hydrochloride (AMB) is an active component, was performed. UV/VIS spectrophotometry and atomic absorption spectroscopy (AAS) were used. Direct and indirect UV/VIS spectrophotometric methods were used for quantitative analysis of AMB and the following recovery value results were obtained: 100,16% and 95,23%, successively. Content of heavy metals in Flavamed® tablets was determined by atomic absorption spetroscopy.
- Subjects
DRUG tablets; BROMHEXINE; DRUG absorption; DRUG derivatives; SPECTROPHOTOMETRY; ATOMIC absorption spectroscopy
- Publication
Quality of Life: A Multi-Disciplinary Journal of Food Science, Environmental Science & Public Health, 2016, Vol 7, Issue 1/2, p24
- ISSN
1986-602X
- Publication type
Article
- DOI
10.7251/QOL16024J