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- Title
Effect of High-intensity Interval Training on Endothelial Function in Type 2 Diabetic Females.
- Authors
Abdi, Shiva; Tadibi, Vahid; Sheikholeslami-Vatani, Dariush
- Abstract
Background: Flow-mediated dilation (FMD) is a noninvasive approach to examine endothelial function. Objectives: The purpose of this study was to investigate the effect of 12 weeks of high-intensity interval training (HIIT) on FMD and circulating levels of adropin and nitric oxide (NO) in females with type 2 diabetes. Methods: Thirty females with type 2 diabetes were randomly assigned into two equal groups of HIIT and control. The exercise program consisted of three sessions a week for 12 weeks. Each training session included 4 x 4-minute running intervals at 85 - 95% of maximal heart rate (HRmax) with 3-minute active recoveries at 50 - 60% of HRmax. Circulating levels of adropin, NO, glucose, HbA1c, insulin, HOMA-IR, as well as lipid profile, and body composition parameters were measured before and after the intervention. Results: A significant increase of FMD% was observed after the intervention in the HIIT group (P = 0.001). In addition, the circulation levels of adropin and NO enhanced as a result of HIIT (P=0.012 and P< 0.001, respectively). There were also significant positive effects on the levels of lipid profile (except for HDL), FBS, and HbA1c; as well as on the insulin resistance and the body composition variables. There were no significant changes in the control group except an increase in the total cholesterol levels (P < 0.01). Conclusions: The results showed that 12 weeks of the HIIT program could improve the endothelial function, glucose-related indices, lipid profile, and body composition variables in females with type 2 diabetes.
- Subjects
ENDOTHELIUM physiology; GLYCOSYLATED hemoglobin; BODY composition; RUNNING; CONVALESCENCE; EXERCISE physiology; TYPE 2 diabetes; RANDOMIZED controlled trials; INSULIN; BLOOD circulation; HEART beat; DESCRIPTIVE statistics; HIGH-intensity interval training; NITRIC oxide; STATISTICAL sampling; PEPTIDES; LIPIDS; INSULIN resistance; CHOLESTEROL
- Publication
Asian Journal of Sports Medicine, 2021, Vol 12, Issue 4, p1
- ISSN
2008-000X
- Publication type
Article
- DOI
10.5812/asjsm.113566