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- Title
Cholesterol-Lowering Bioactive Foods and Nutraceuticals in Pediatrics: Clinical Evidence of Efficacy and Safety.
- Authors
Fogacci, Federica; ALGhasab, Naif Saad; Di Micoli, Valentina; Giovannini, Marina; Cicero, Arrigo Francesco Giuseppe
- Abstract
Long-term exposure to even slightly elevated plasma cholesterol levels significantly increases the risk of developing cardiovascular disease. The latest evidence recommends an improvement in plasma lipid levels, even in children who are not affected by severe hypercholesterolemia. The risk–benefit profile of pharmacological treatments in pediatric patients with moderate dyslipidemia is uncertain, and several cholesterol-lowering nutraceuticals have been recently tested. In this context, the available randomized clinical trials are small, short-term and mainly tested different types of fibers, plant sterols/stanols, standardized extracts of red yeast rice, polyunsaturated fatty acids, soy derivatives, and some probiotics. In children with dyslipidemia, nutraceuticals can improve lipid profile in the context of an adequate, well-balanced diet combined with regular physical activity. Of course, they should not be considered an alternative to conventional lipid-lowering drugs when necessary.
- Subjects
HYPERCHOLESTEREMIA; HYPERLIPIDEMIA; LIPIDS; UNSATURATED fatty acids; FUNCTIONAL foods; LDL cholesterol; PHYTOSTEROLS; PLANT extracts; DIETARY fiber; PROBIOTICS; DIETARY supplements; RED yeast rice; SOYFOODS; PHYSICAL activity
- Publication
Nutrients, 2024, Vol 16, Issue 10, p1526
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu16101526