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- Title
The protective role of chrysin on harmful effects of formaldehyde on the development of hippocampus in rat fetuses; a histopathologic study.
- Authors
Cuglan, S.; Yildiz, A.; Irmak Sapmaz, H.; Bakirci, S.; Kose, E.; Ekinci, N.
- Abstract
Objectives: In this study, we aimed to determine possible harmful effects of formaldehyde exposure on the hippocampus of fetuses. In addition, potential protective role of chrysin (CH) against these effects. Methods: 58 female rats were divided into 6 groups and were tried to become pregnant. 10 rats which were not pregnant excluded from the study. It was administered every other day during 7-20 days of pregnancy to group I (Control) intraperitoneally (i.p.) saline, group II (CH) by gavage 20 mg/kg CH, group III (FA-0,1) i.p. 0,1 mg/kg FA, group IV (FA-1) i.p. 1 mg/kg FA, group V (FA-0,1+CH) i.p. 0,1 mg/kg FA and by gavage 20 mg/kg CH and group VI (FA-1+CH) i.p. 1 mg/kg FA and by gavage 20 mg/kg CH. CH was applied one day before FA application. Fetuses obtained by caesarean section. Histological staining was performed to determine the impact on the hippocampus development in fetuses. Stained preparations were examined with a study microscope (Leica DFC- 280). Statistical analysis was performed. Results: In the pyramidal layer of the FA groups section was observed mild decrease in neuronal density, neuronal shrinkage and condensation of the nucleus. These observed changes were prominent in the group of FA-1. Histopathological injury of the FA-1 group significantly higher than the control group (p<0.05). Some sections in the FA groups were observed apoptotic cells in the pyramidal layer. Injury scores in the groups treated FA with CH decreased compared to the group treated with only FA. However, this reduction was not found to be statistically significant (p>0.05). Conclusion: It was determined that low dose FA exposure leads to histological damages on the development of the hippocampus of the rat fetuses. Although these effects were prevented by CH, these changes were not statistically significant.
- Subjects
FORMALDEHYDE; RAT diseases; CESAREAN section
- Publication
Anatomy: International Journal of Experimental & Clinical Anatomy, 2014, Vol 8, pS76
- ISSN
1307-8798
- Publication type
Abstract