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- Title
Evaluating Postoperative Outcomes and Investigating the Usefulness of EU-TIRADS Scoring in Managing Pediatric Thyroid Nodules Bethesda 3 and 4.
- Authors
Uğurlu, Aylin Kılınç; Bitkay, Abdurrahman; Gürbüz, Fatih; Karakuş, Esra; Ilıkan, Gülşah Bayram; Damar, Çağrı; Şahin, Seda; Kıran, Merve Meryem; Gülaldı, Nedim; Azılı, Müjdem Nur; Şenel, Emrah; İlhan, İnci Ergürhan; Boyraz, Mehmet
- Abstract
Objective: The aim was to assess postoperative outcomes in pediatric thyroid nodules with atypia of undetermined significance (AUS/ FLUS) or suspicious for a follicular neoplasm (SFN) and their respective the European-Thyroid Imaging Reporting and Data System (EUTIRADS) scores. Methods: Forty-four pediatric patients at a single center with thyroid nodules classified as AUS/FLUS or SFN from August 2019 to December 2022 were retrospectively reviewed. Data on demographics, thyroid function, nodule size, and ultra sonographic features were collected. Postoperative pathologies were categorized into benign, low-risk, and malignant neoplasms according to the World Health Organization 2022 criteria, and EU-TIRADS was used for retrospective radiological scoring. Results: Among 21 (47.7%) of patients who had surgical intervention, 72% had Bethesda 3 and 28% had Bethesda 4 thyroid nodules. Post-surgical histopathological classifications were 43% benign, 19% low-risk, and 38% malignant. Of note, EU-TIRADS 3 and 5 scores were present in 44% and 56% of the benign cases, respectively. Malignant cases tended to produce higher EU-TIRADS scores, with 64% rated as EU-TIRADS 5. Bethesda category 4 nodules had a 66% malignancy rate, significantly higher than the 27% in category 3. Conclusion: A substantial proportion of histologically benign cases were classified as EU-TIRADS 5, suggesting that EU-TIRADS may lead to unnecessary biopsies in benign cases. Malignant cases were more likely to have a higher EU-TIRADS score, indicating a positive correlation with malignancy risk, particularly in Bethesda 4 cases. However, the EU-TIRADS system’s predictive value for malignancy in Bethesda 3 cases was poorer.
- Subjects
THYROID gland tumors; TREATMENT effectiveness; RETROSPECTIVE studies; ULTRASONIC imaging; SURGICAL complications; MEDICAL records; ACQUISITION of data; NEEDLE biopsy; COMPARATIVE studies; THYROIDECTOMY; EVALUATION; ADOLESCENCE
- Publication
Journal of Clinical Research in Pediatric Endocrinology, 2024, Vol 16, Issue 2, p160
- ISSN
1308-5727
- Publication type
Article
- DOI
10.4274/jcrpe.galenos.2024.2023-8-12