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- Title
!e Association between Periodontitis and Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-analysis.
- Authors
Wijarnpreecha, Karn; Panjawatanan, Panadeekarn; Cheungpasitporn, Wisit; Lukens, Frank J.; Harnois, Denise M.; Pungpapong, Surakit; Ungprasert, Patompong
- Abstract
Background & Aims: Recent studies have suggested an association between periodontitis and nonalcoholic fatty liver disease (NAFLD) although the results were inconsistent. "e current systematic review and metaanalysis was conducted with the aim to comprehensively investigate this possible association by identifying all relevant studies and combining their results together. Methods: A comprehensive literature review was conducted utilizing the MEDLINE and EMBASE databases through December 2019 to identify all studies that compared the risk of NAFLD among patients with periodontitis to individuals without periodontitis. E!ect estimates from each study were extracted and combined using the random-e!ect, generic inverse variance method of DerSimonian and Laird. Results: A total of #ve studies with 27,703 participants ful#lled the eligibility criteria and were included in the meta-analysis. All #ve studies reported the magnitude of association between NAFLD and periodontitis that was diagnosed based on the periodontal pocket depth of > 3.5-4 mm. "e pooled OR of unadjusted analysis was 1.48 (95%CI: 1.15-1.89; I2 92%). However, when adjusted results from the primary studies were used, pooled OR decreased to 1.13 and lost its statistical signi#cance (95%CI: 0.95-1.35; I2 67%). "ree studies reported the magnitude of association between NAFLD and periodontitis that was diagnosed based on a clinical attachment level of $ 3 mm. "e pooled OR of unadjusted analysis was 1.13 (95%CI: 1.07-1.20; I2 0%). However, when adjusted results from the primary studied were used, pooled OR decreased to 1.08 and lost its statistical signi#cance (95%CI: 0.94-1.24; I2 58%) Conclusions: "e study found a signi#cant association between periodontitis and NAFLD. However, the association lost its signi#cance when various metabolic parameters were adjusted, suggesting that those metabolic conditions, not periodontitis itself, were predisposing factors for NAFLD.
- Subjects
PERIODONTAL pockets; FATTY liver; PERIODONTITIS; META-analysis
- Publication
Journal of Gastrointestinal & Liver Diseases, 2020, Vol 29, Issue 2, p211
- ISSN
1841-8724
- Publication type
Article
- DOI
10.15403/jgld-841