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- Title
The Epidemiology, Diagnosis, and Management of Aristolochic Acid Nephropathy.
- Authors
Gökmen, M. Refik; Cosyns, Jean-Pierre; Arlt, Volker M.; Stiborová, Marie; Phillips, David H.; Schmeiser, Heinz H.; Simmonds, Monique S. J.; Cook, Terence; Vanherweghem, Jean-Louis; Nortier, Joëlle L.; Lord, Graham M.
- Abstract
It has been 20 years since the first description of a rapidly progres-sive renal disease that is associated with the consumption of Chi-nese herbs containing aristolochic acid (AA) and is now termed aristolochic acid nephropathy (AAN). Recent data have shown that AA is also the primary causative agent in Balkan endemic nephrop-athy and associated urothelial cancer. Aristolochic acid nephropathy is associated with a high long-term risk for renal failure and urothe-lial cancer, and the potential worldwide population exposure is enormous. This evidence-based review of the diagnostic approach to and management of AAN draws on the authors' experience with the largest and longest-studied combined cohort of patients with this condition. It is hoped that a better understanding of the im-portance of this underrecognized and severe condition will improve epidemiologic, preventive, and therapeutic strategies to reduce the global burden of this disease.
- Subjects
KIDNEY disease treatments; CHINESE medicine; HERBAL medicine; ARISTOLOCHIC acid; TRANSITIONAL cell carcinoma; KIDNEY failure; EVIDENCE-based medicine; DISEASE risk factors
- Publication
Annals of Internal Medicine, 2013, Vol 158, Issue 6, p469
- ISSN
0003-4819
- Publication type
Article
- DOI
10.7326/0003-4819-158-6-201303190-00006