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- Title
Emerging Therapeutic Options for Celiac Disease: Potential Alternatives to a Gluten-Free Diet.
- Authors
Bakshi, Anita; Stephen, Sindu; Borum, Marie L.; Doman, David B.
- Abstract
Celiac disease is an autoimmune disorder of the small intestine that is more common than was previously thought. This disease is caused by an inappropriate immune response to wheat gluten, barley, and rye. Three main pathways cause celiac disease: the environmental trigger (gluten), genetic susceptibil- ity, and unusual gut permeability. The only treatment currently available is a strict gluten-free diet. Unfortunately, a majority of patients have difficulty complying with this diet, and the response to therapy is poor. Therefore, alternative treatments are being developed, and new insights into the pathophysiology of celiac disease have led to research into novel therapies. New treat- ments include engineering gluten-free grains, decreasing intes- tinal permeability by blockage of the epithelial zonulin receptor, inducing oral tolerance to gluten with a therapeutic vaccine, and degrading immunodominant gliadin peptides using probiot- ics with endopeptidases or transglutaminase inhibitors. These nondiet-based therapies provide hope for enhanced, lifelong celiac disease management with improved patient compliance and better quality of life.
- Subjects
CELIAC disease; IMMUNIZATION; QUALITY of life; GENETICALLY modified foods; PROBIOTICS; INVESTIGATIONAL drugs; PREVENTION
- Publication
Gastroenterology & Hepatology, 2012, Vol 8, Issue 9, p582
- ISSN
1554-7914
- Publication type
Article