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- Title
Efficacy of motile sperm organelle morphology examination (MSOME) and sperm head vacuoles evaluation in conventional IVF versus ICSI cycles.
- Authors
Ghazali Sh.; Talebi A. R.; Khalili M. A.; Atlatoonian A.; Anbari F.; Halvaei I.; Nabi A.
- Abstract
Introduction: The impact of MSOME criteria on ICSI outcomes is a controversial issue in the literature. There are rare studies regarding the association between anteroposterior sperm head size, cytoplasmic droplet, head shape and conventional sperm parameters. To the best of our knowledge, the prevalence of sperm deformities using MSOME has not been reported in conventional IVF cycles. Materials and Methods: This is a prospective analysis of MSOME parameters in IVF (n=31) and ICSI cycles (n=35) performed from 2013 to 2014. MSOME parameters were evaluated as follows: vacuole: none, small, medium, large and mix; head size: normal, small and large; cytoplasmic droplet; head shape and acrosome normality. We compared the association between MSOME and conventional sperm parameters, early embryo development and pregnancy outcomes. Results: In IVF group, the rate of large nuclear vacuole (LNV) was significantly lower in successful pregnancies compared to non-pregnant patients (7.38±4.4 vs. 13.81±9.7, respectively, p=0.045). Conversely, the rate of small nuclear vacuoles (SNVs) showed increased level in positive pregnancies. There was a positive correlation between the rates of nonvacuoles, SNVs and normal sperm shape (p<0.0001 and p=0.003, respectively). A negative correlation was found between the rate of LNVs and normal sperm shape. Moreover there was a positive correlation between progressive motility and normal head size. In ICSI group, we did not observe any association between MSOME criteria and pregnancy outcome. The rate of LNVs and large head sperm size illustrated significantly positive correlation with the percentage of nonprogressive motile sperm. Also, the cytoplasmic droplet had negative effect on sperm shape (p=0.04). Conclusion: The LNV has negative effect on sperm shape normality and pregnancy outcome in IVF cycles. However, there was no any association between MSOME parameters and early embryo development and pregnancy outcome in ICSI cycles.
- Subjects
SPERM motility; INTRACYTOPLASMIC sperm injection
- Publication
Iranian Journal of Reproductive Medicine, 2015, p17
- ISSN
1680-6433
- Publication type
Abstract