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- Title
Anti-HIV-1 activity of lignans from the fruits of Schisandra rubriflora.
- Authors
Xiao, Wei-Lie; Wang, Rui-Rui; Zhao, Wei; Tian, Ren-Rong; Shang, Shan-Zhai; Yang, Liu-Meng; Yang, Jian-Hong; Pu, Jian-Xin; Zheng, Yong-Tang; Sun, Han-Dong
- Abstract
This study investigated the 70% aqueous acetone extract of the fruits of Schisandra rubriflora which led to the isolation of eight lignans, including a new isolate, rubrisandrin C ( 1), and seven known lignans ( 2– 8). The structure of 1 was established by extensive 1D and 2D NMR spectroscopy and its absolute stereochemistry was determined by CD spectrum. Compounds 1– 5 and 7– 8 were evaluated for their anti-HIV-1 activity that showed inhibitory activity on HIV-1IIIB induced syncytium formation with EC50 values in the range of 2.26∼20.4 μg/mL. Compounds 1 and 7 exerted their obvious protection of HIV-1IIIB inducted MT-4 host cells lytic effects with a selectivity index of 15.4 and 24.6, respectively.
- Publication
Archives of Pharmacal Research, 2010, Vol 33, Issue 5, p697
- ISSN
0253-6269
- Publication type
Article
- DOI
10.1007/s12272-010-0508-7