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- Title
Drug release from thermo-responsive self-assembled polymeric micelles composed of cholic acid and poly( N-isopropylacrylamide).
- Authors
Kim, In-Sook; Jeong, Young-Il; Lee, Yun-Ho; Kim, Sung-Ho
- Abstract
Cholic acid, conjugated with amine-terminated poly( N-isopropylacrylamide) (abbreviated as CA/ATPNIPAAm), was synthesized by a N, N′-dicyclohexyl carbodiimide (DCC)-mediated coupling reaction. Self-assembled CA/ATPNIPAAm micelles were prepared by a diafiltration method in aqueous media. The CA/ATPNIPAAm micelles exhibited a lower critical solution temperature (LCST) at 31.5°C. Micelle sizes measured by photon correlation spectroscopy (PCS) were approximately 31.6±5.8 nm. The CA/ATPNIPAAm micelles were spherical and their thermal size transition was observed by transmission electron microscope (TEM). A fluorescence probe technique was used for determining the micelle formation behavior of CA/ATPNIPAAm in aqueous solutions using pyrene as a hydrophobic probe. The critical micelle concentration (CMC) was evaluated as 8.9×10−2 g/L. A drug release study was performed using indomethacin (IN) as a hydrophobic model drug. The release kinetics of IN from the CA/ATPNIPAAm micelles revealed a thermo-sensitivity by the unique character of poly( N-isopropylacrylamide) i.e. the release rate was higher at 25°C than at 37°C.
- Publication
Archives of Pharmacal Research, 2000, Vol 23, Issue 4, p367
- ISSN
0253-6269
- Publication type
Article
- DOI
10.1007/BF02975449