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- Title
Synthesis and evaluation of cytotoxicity of novel arylsulfonylimidazolidinones containing sulfonylurea pharmacophore.
- Authors
Jung, Sang-Hun; Song, Jae-Shin; Lee, Hui-Soon; Choi, Sang-Un; Lee, Chong-Ock
- Abstract
Design and synthesis of novel 4-phenyl-1-arylsulfonylimidazolones 3 and 4-phenyl-3-arylsulfonylimidazolones 4 and evaluation of their cytotoxic activity against eleven human cancer cell lines and two murine leukemia cell lines in vitro were performed. As a result, a series of 4-phenyl-1(N)-arylsulfonylimidazolones ( 3) has been found to be the potential anticancer agent. Compounds 3b, 3c, and 3d exhibit strong activity as indicated by their IC values 0.39, 3.19, 0.31 μg/mL against A549 and 0.80, 0.48, 0.0007 μg/mL against SK-Mel-2, respectively. These compounds also possess much more potent activity (10-1000 times) than LY186641 against eleven other cell lines.
- Publication
Archives of Pharmacal Research, 1996, Vol 19, Issue 6, p570
- ISSN
0253-6269
- Publication type
Article
- DOI
10.1007/BF02986031