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- Title
Contrast-enhanced.
- Authors
Haerle, Stephan K.; Strobel, Klaus; Ahmad, Nader; Soltermann, Alex; Schmid, Daniel T.; Stoeckli, Sandro J.
- Abstract
Background. Cystic lymph node metastasis (CLNM) is commonly found in human papillomavirus (HPV)- associated tonsillar squamous cell carcinoma (SCC). The aim of this study was to compare the accuracy in detecting cystic lymph node metastasis from tonsillar SCC between contrast-enhanced CT, 18F- fluorodeoxyglucose-positron emission tomography (FDG-PET), non-enhanced 18F-FDG-PET/CT, and contrast-enhanced 18F-FDG-PET/CT. Methods. Thirty-four patients with a tonsillar SCC undergoing a pretreatment contrast-enhanced 18F-FDG-PET/CT followed by a neck dissection as a standard of reference were included. The contrast-enhanced CT part, the 18F-FDG-PET part, the non-enhanced 18F-FDG-PET/CT part, and the contrast- enhanced 18F-FDG-PET/CT were assessed separately for correct N classification and the differentiation of N0 versus N+. Results. Contrast-enhanced 18F-FDG-PET/CT, non-enhanced 18F-FDG-PET/CT, and contrast-enhanced CT are equally accurate for correct neck staging. Regarding pN0 versus pN+, contrastenhanced CT and contrast-enhanced 18F-FDG-PET/CT are superior to non-enhanced 18F-FDG-PET/CT (p = .017). Conclusion. Contrast-enhanced CT and contrast-enhanced 18F-FDG-PET/CT perform equally and better than non-enhanced 18F-FDG-PET/CT in detecting CLNM in tonsillar SCC. Therefore, in patients scheduled for 18F-FDG-PET/CT, we strongly suggest performing a contrast-enhanced 18F-FDGPET/ CT, which is not routine in most centers.
- Subjects
LYMPH node diseases; METASTASIS; PAPILLOMAVIRUSES; SQUAMOUS cell carcinoma; TONSIL cancer; NECROSIS; PAPILLOMAVIRUS diseases; POSITRON emission tomography; DIAGNOSIS
- Publication
Head & Neck, 2011, Vol 33, Issue 3, p324
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.21447