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- Title
The mechanism of poly I:C-induced antiviral activity in peritoneal macrophage.
- Authors
Pyo, Suhkneung
- Abstract
Macrophages play an important role in defense against virus infection by intrinsic resistance and by extrinsic resistance. Since interferon-induced enzymes which are 2′-5′ oligoadenylate synthetase and P1/elF-2 protein kinase have been shown to be involved in the inhibition of viral replication, I examined the mechanism by which poly I:C, an interferon inducer, exerts its antiviral effects in inflammatory macrophages infected with herpes simplex virus type 1 (HSV-1). The data presented here demonstrate that poly I:C-induced antiviral activity is partially due to the activation of 2′-5′ oligoadenylate synthetase. The activation of 2′-5′ oligoadenylate A synthetase by poly I:C is also at least partly mediated via the production of interferon-β. Taken together, these data indicate that interferon-β produced in response to poly I:C acts in an autocrine manner to activate the 2′-5′ oligoadenylate synthetase and to induce resistance to HSV-1.
- Publication
Archives of Pharmacal Research, 1994, Vol 17, Issue 2, p93
- ISSN
0253-6269
- Publication type
Article
- DOI
10.1007/BF02974230