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- Title
Early H elicobacter pylori eradication is associated with a reduced risk of recurrent peptic ulcers in cirrhotic patients.
- Authors
Chang, Shen‐Shong; Hu, Hsiao‐Yun
- Abstract
Obiective The study aimed to investigate whether early Helicobacter pylori ( H. pylori) eradication therapy in cirrhotic patients caused a dramatic reduction of recurrent peptic ulcers compared with those treated with a late eradication. Methods We identified cirrhotic patients using the International Classifications of Diseases, Revision 9 ( ICD-9- CM). Decompensated cirrhotic patients can apply for a catastrophic illness card and were identified via the ICD-9- CM codes 571.2, 571.5 and 571.6. Compensated cirrhotic patients were identified via the ICD-9- CM codes 571.2, 571.5 and 571.6, after excluded decompensated cirrhotic patients. We categorized patients into early (time lag ≤365 days after peptic ulcer diagnosis) and late (time lag >365 days) H. pylori eradication therapy groups. The end-point was the occurrence of recurrent peptic ulcers. Cox proportional hazards model was used to calculate the hazard ratios ( HRs). Results Altogether, 154 cirrhotic patients were included in the early H. pylori eradication group and 103 in the late H. pylori eradication group. Cirrhotic patients had a higher risk of recurrent peptic ulcers in the late H. pylori eradication group (HR 1.58, 95% CI 1.09-2.28, P = 0.015). However, the risk of recurrent peptic ulcers in alcoholic cirrhotic patients in both groups ( HR 1.47, 95% CI 0.77-2.83, P = 0.247) was similar. Conclusions Early H. pylori eradication is associated with a lower risk of recurrent peptic ulcers in cirrhotic patients. H. pylori eradication is the mainstay for treating cirrhotic patients who have contracted peptic ulcers.
- Subjects
HELICOBACTER pylori; PEPTIC ulcer; GASTROINTESTINAL hemorrhage; CIRRHOSIS of the liver; PROPORTIONAL hazards models; DISEASE complications
- Publication
Journal of Digestive Diseases, 2014, Vol 15, Issue 8, p451
- ISSN
1751-2972
- Publication type
Article
- DOI
10.1111/1751-2980.12159