We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Improvement of Postprandial Lipid Metabolism After Ileal Transposition in Non-obese Diabetic Rats.
- Authors
Chen, Weijie; Yin, Haixin; Zhang, Ning; Liu, Wei; Qu, Qiang; Xiao, Jianchun; Gong, Fengying; He, Xiaodong
- Abstract
Background: Ileal transposition (IT) could reduce obesity and improve type 2 diabetes mellitus (T2DM). The main aim of our study was to investigate lipid metabolism changes in T2DM rats after IT without a weight reduction effect. Methods: Thirty male diabetic rats were randomly divided into IT, sham IT (SI), and control groups. The levels of plasma cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglycerides (TGs), and bile acid were measured. After sacrifice, the white adipose tissue, brown adipose tissue and liver were weighed. Results: IT induced significant improvement in glucose and lipid metabolism. There were no significant differences in the levels of cholesterol (P = 0.87), HDL (P = 0.70), LDL (P = 0.96), or TGs (P = 0.97) among the groups before surgery. After IT, the levels of cholesterol (P = 0.019), LDL (P = 0.004), and TGs (P < 0.001) were lower than those in the SI and control groups, while the level of HDL was not significantly different compared to those of the other groups (P = 0.437). Higher bile acid level (P = 0.001), lower white adipose tissue/total body weight ratio (P < 0.001), and lower liver/total body weight ratio (P = 0.003) were found in the IT group. The BAT/total body weight ratio in the IT group was higher than that in the SI or control groups (P = 0.002). Conclusions: IT could improve lipid metabolism in diabetic rats.
- Subjects
LIPID metabolism; WHITE adipose tissue; WEIGHT loss; TYPE 2 diabetes; BROWN adipose tissue; ILEAL conduit surgery
- Publication
Obesity Surgery, 2021, Vol 31, Issue 4, p1572
- ISSN
0960-8923
- Publication type
Article
- DOI
10.1007/s11695-020-05158-z