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- Title
Lubiprostone Decreases the Small Bowel Transit Time by Capsule Endoscopy: An Exploratory, Randomised, Double-Blind, Placebo-Controlled 3-Way Crossover Study.
- Authors
MizueMatsuura; Masahiko Inamori; Hiroki Endo; Tetsuya Matsuura; Kenji Kanoshima; Yumi Inoh; Yuji Fujita; Shotaro Umezawa; Akiko Fuyuki; Shiori Uchiyama; Takuma Higurashi; Hidenori Ohkubo; Eiji Sakai; Hiroshi Iida; Takashi Nonaka; Seiji Futagami; Akihiko Kusakabe; Shin Maeda; Atsushi Nakajima
- Abstract
The aim of this study was to investigate the usefulness of lubiprostone for bowel preparation and as a propulsive agent in small bowel endoscopy. Six healthy male volunteers participated in this randomized, 3-way crossover study. The subjects received a 24 μg tablet of lubiprostone 60 minutes prior to the capsule ingestion for capsule endoscopy (CE) and a placebo tablet 30 minutes before the capsule ingestion (L-P regimen), a placebo tablet 60 minutes prior to CE and a 24 μg tablet of lubiprostone 30 minutes prior to CE (P-L regimen), or a placebo tablet 60 minutes prior to r CE and a placebo tablet again 30 minutes prior to CE (P-P regimen). The quality of the capsule endoscopic images and the amount of water in the small bowel were assessed on 5-point scale. The median SBTT was 178.5 (117-407) minutes in the P-P regimen, 122.5 (27-282) minutes in the L-P regimen, and 110.5 (11-331) minutes in the P-L regimen (P = 0.042). This study showed that the use of lubiprostone significantly decreased the SBTT. We also confirmed that lubiprostone was effective for inducing water secretion into the small bowel during CE.
- Subjects
ENDOCRINE secretions; EXCRETION; NATURAL resources; WATER activity of food; WATER damage
- Publication
Gastroenterology Research & Practice, 2014, p1
- ISSN
1687-6121
- Publication type
Article
- DOI
10.1155/2014/879595