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- Title
Enhanced Fluoride Bioavailability with Incorporation of Arginine in Child Dentifrices.
- Authors
Bijle, Mohammed Nadeem; Tsoi, James; Ekambaram, Manikandan; Lo, Edward C. M.; Carey, Clifton M.; Kar Yung Yiu, Cynthia; Yiu, Cynthia Kar Yung
- Abstract
<bold>Objective(s): </bold>To: 1) examine the fluoride concentrations in commercial child formula dentifrices (CFD)s; and 2) investigate the effect of arginine incorporation in CFDs on fluoride bioavailability.<bold>Study Design: </bold>Five commercial CFDs were examined for fluoride concentrations. Total, total soluble, and insoluble fluorides in CFDs were determined by the modified Taves acid-diffusion method (TAD). Ionic F and MFP were estimated by modified direct method with standard addition technique. L-arginine (L-Arg)/L-arginine monohydrochloride (L-Arg.HCl) were incorporated at 2% w/w in the commercial CFDs. The pH of the toothpaste slurries, buffer capacity of the added Arg, potentially available fluorides (PAF) and 1-min PAF by TAD were determined.<bold>Results: </bold>The CFDs had 4 to 32% of insoluble fluorides. Addition of L-Arg/L-Arg.HCl significantly improved the fluoride bioavailability in CFDs (p<0.05). Incorporation of L-Arg significantly increased the pH of toothpaste slurries (p<0.05); while L-Arg.HCl decreased the pH. Principal component analysis showed that L-Arg.HCl decreased the pH of toothpaste slurries due to the presence of Cl in the form of HCl; whereas the inherent elements/molecules (Na/P/Pi/F) remain distinct with unidentified influence on the variables.<bold>Conclusion(s): </bold>The CFDs containing NaF only have higher concentrations of bioavailable fluoride. Incorporating arginine (L-arginine or L-arginine monohydrochloride) at 2% w/w improves fluoride bioavailability of the child formula dentifrices.
- Subjects
DENTIFRICES; TOOTHPASTE; ARGININE; FLUORIDES; BIOAVAILABILITY; PRINCIPAL components analysis; COMMERCIAL art; SODIUM compounds; CARIOSTATIC agents; PHOSPHATES
- Publication
Journal of Clinical Pediatric Dentistry, 2020, Vol 44, Issue 5, p332
- ISSN
1053-4628
- Publication type
journal article
- DOI
10.17796/1053-4625-44.5.7