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- Title
An lnterleukin-6 Gene Promoter Polymorphism and Unexplained Late Intrauterine Fetal Death: A Multicenter Study.
- Authors
Huber, Ambros; Grimm, Christoph; Jirecek, Stefan; Zeillinger, Robert; Heim, Kurt; Husslein, Peter; Hefler, Lukas
- Abstract
Objective: Interleukin-6 (IL-6)-mediated inflammatory processes have been proposed to be involved in the pathogenesis of pregnancy-associated complications such as late unexplained intrauterine fetal death (IUFD). Therefore we determined whether a common guanine/cytosine polymorphism at position-174 of the promoter of the IL-6 gene (1L6) known to affect in vivo protein activity can serve as candidate genefor this condition.Methods: In a multicenter case-control study, we evaluated the IL6 promoter polymorphism by pyrosequencing in 92 women with IUFD. Ninety-four healthy women with at least one uncomplicated full-term pregnancy and no history of IUFD served as the control group.Results: No significant association was found between the presence of at least one mutant allele of the IL6 promoter polymorphism (P = .2; odds ratio = 1.5 [95% confidence interval, 0.8-2.7]) and the incidence of IUFD. In women with IUFD, the presence of at least one mutant allele of the IL6 promoter polymorphism did not influence timing offetal death (33.9 [5. 1]gestational weeks vs 34. 1 [4.9]gestational weeks, P = .8) or birth weight (2055 [1119] g vs 1963 [992] g, P = .7).Conclusion: To our knowledge, we are thefirst to report on a common polymorphism of the IL6 promoter gene in women with late IUFD. The investigated IL6 promoter polymorphism can not be seen as candidate gene for IUFD in Caucasian women.
- Publication
Reproductive Sciences, 2005, Vol 12, Issue 1, p33
- ISSN
1933-7191
- Publication type
Article
- DOI
10.1016/j.jsgi.2004.08.001