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- Title
A Jekyll and Hyde Profile: Type 1 Interferon Signaling Plays a Prominent Role in the Initiation and Maintenance of a Persistent Virus Infection.
- Authors
Oldstone, Michael B. A.
- Abstract
The hallmarks of persistent viral infections are exhaustion of virus-specific T cells, elevated production of interleukin 10 (IL-10) and programmed death-1 (PD-1) the dominant negative regulators of the immune system and disruption of secondary lymphoid tissues. Within the first 12-24 hours after mice are infected with lymphocytic choriomeningitis virus (LCMV) clone 13, which is used as a model of persistent virus infection, we note generation of high titers of type 1 interferon. Blockade of type 1 interferon significantly lessens IL-10 and PD-1/PD-L1, allows normal secondary lymphoid architecture and re-establishes antiviral T-cell function, thus eradicating the virus and clearing the infection. Hence, type 1 interferon is a master reostat for establishing persistent viral infection.
- Subjects
PERSISTENT viral diseases; INTERFERONS; VIRAL cell cycle; T cells; INTERLEUKIN-10; APOPTOSIS
- Publication
Journal of Infectious Diseases, 2015, Vol 212, pS31
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1093/infdis/jiu501