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- Title
Properties of pramlintide and insulin upon mixing.
- Authors
Weyer, Christian; Fineman, Mark S.; Strobel, Susan; Shen, Larry; Data, Joann; Kolterman, Orville G.; Sylvestri, Mario F.
- Abstract
Purpose. The pharmacokinetics, pharmacodynamics, and safety of pramlintide and various insulin formulations in patients with type 1 diabetes mellitus (DM) when given as separate injections or mixed in the same syringe before injection were studied. Methods. In two randomized, open-label, placebo-controlled, five-period-crossover studies, patients with type 1 DM received preprandial injections of pramlintide, short-acting insulin, and long-acting insulin administered either by separate injections or after mixing in various combinations. Serum free insulin and plasma glucose concentrations were measured for 10 hours and plasma pramlintide concentrations for 5 hours after injection. Results. Blood samples were collected from a total of 51 patients. All treatments involving mixtures were comparable to separate injections with respect to the area under the concentration-versus-time curve (AUC) and the maximum concentration (Cmax) of serum free insulin. There were some minor differences in the AUC and Cmax of pramlintide. No injection-site reactions or other unexpected adverse events were observed. Conclusion. Mixing pramlintide with short- or long-acting insulin in the same syringe before subcutaneous injection did not affect the pharmacodynamics of glucose or the pharmacokinetics of insulin or pramlintide in a clinically significant manner.
- Subjects
INSULIN; BLOOD plasma; HYPOGLYCEMIC agents; HORMONES; PROINSULIN; PANCREATIC secretions
- Publication
American Journal of Health-System Pharmacy, 2005, Vol 62, Issue 8, p816
- ISSN
1079-2082
- Publication type
Article
- DOI
10.1093/ajhp/62.8.816