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- Title
Cloning and Expression of Human GTDC1 Gene (Glycosyltransferase-Like Domain Containing 1) from Human Fetal Library.
- Authors
Enpeng Zhao; Yao Li; Xuping Eu, Heidar-Ali; Jia-yl Zhang, Heidar-Ali; Huawu Zeng; Li Zeng; Yun Lin; Jinzhong Chen; Gang Yin; Ji Qian; Kang Ying; Yl Xie, Heidar-Ali; Robert Chunhua Zhao; Yu-min Mao
- Abstract
The glycosyltransferases (GTs) catalyze the synthesis of the carbohydrate portions of glycoproteins, glycolipids, and proteoglycans. Here we report the cloning and characterization of a novel human GTDC1 (glycosyltransferase-like domain containing 1) gene, which locates on human chromosome 2q22. The GTDC1 cDNA is 2954 bp in length, encoding a putative protein of 458 amino acids. At protein level human GTDC1 has 75 and 37% identity with its homologous counterparts in the mouse and fruitfly, respectively. RT-PCR analysis revealed its relatively high expression level in the adult lung, spleen, testis, and peripheral blood leukocyte.
- Subjects
HUMAN genetics; CLONING; GLYCOSYLTRANSFERASES; CARBOHYDRATES; HUMAN chromosomes; GENETICS
- Publication
DNA & Cell Biology, 2004, Vol 23, Issue 3, p183
- ISSN
1044-5498
- Publication type
Article
- DOI
10.1089/104454904322964788