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- Title
Salivary IgA and periodontal treatment needs in diabetic patients.
- Authors
Branco-de-Almeida, Luciana Salles; Coêlho Alves, Cláudia Maria; Lopes, Fernanda Ferreira; Vasconcelos Pereira, Adriana de Fátima; Meireles Guerra, Rosane Nassar; Amaral Pereira, Antônio Luiz
- Abstract
Salivary IgA can serve as a first line of defense against pathogens that colonize and invade mucosal surfaces and may be protective against periodontal disease. The aim of this study was to assess salivary immunoglobulin A levels in diabetic and non-diabetic patients with different periodontal treatment needs. The Periodontal Screening & Recording (PSR) system was used to evaluate the periodontal treatment needs of 41 diabetic and 42 non-diabetic patients. Unstimulated whole saliva was collected from each patient immediately before clinical examination and stored at -20 °C until analysis. Salivary immunoglobulin A (s-IgA) levels were determined using an enzyme-linked immunosorbent assay, and values were expressed as optical density. Diabetic and non-diabetic patients were compared using clinical and laboratory data. PSR data indicated that periodontal disease was more frequent and more severe in diabetic patients. A higher prevalence of codes 3 and 4 was observed in diabetics as compared with non-diabetics (odds ratio = 2, P < 0.05). Furthermore, non-diabetic patients had more healthy sextants (code 0) than did diabetic patients. Over half of diabetic patients (∼54%) presented with s-IgA levels that were lower than the normal range (optical density from 0.4 nm to 0.6 nm; P < 0.05). In addition, diabetic patients showed a higher variability in s-IgA levels as compared with non-diabetic patients. In conclusion, diabetic individuals had lower s-IgA levels, more-frequent and more-severe periodontal disease, and a greater need for periodontal treatment as compared with non-diabetic patients.
- Subjects
PERIODONTAL disease; IMMUNOGLOBULINS; PEOPLE with diabetes; PATHOGENIC microorganisms; OPACITY (Optics)
- Publication
Brazilian Oral Research, 2011, Vol 25, Issue 6, p550
- ISSN
1806-8324
- Publication type
Article
- DOI
10.1590/S1806-83242011000600013