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- Title
Screening for IgG4-type anti-nuclear antibodies in IgG4-related disease.
- Authors
Kazuhiro Kiyama; Hajime Yoshifuji; Tsugumitsu Kandou; Yuji Hosono; Koji Kitagori; Ran Nakashima; Yoshitaka Imura; Naoichiro Yukawa; Koichiro Ohmura; Takao Fujii; Daisuke Kawabata; Tsuneyo Mimori
- Abstract
Background: Immunoglobulin (Ig) G4-related disease (IgG4-RD) is characterized by elevated serum IgG4 and infiltration of IgG4+ plasma cells into multiple organs. It is not known whether serum IgG4 is autoreactive in IgG4-RD. Methods: We measured anti-nuclear antibody (ANA) in 19 IgG4-RD cases, determined IgG subclasses of the ANA, and compared them with those of other systemic autoimmune diseases (systemic lupus erythematosus, Sjögren's syndrome, systemic sclerosis, and polymyositis), using subclass-based ANA test (indirect immunofluorescence). Results: 58 % of IgG4-RD cases were ANA-positive (cut-off: 1:40). Whereas their subclass of ANA was predominantly IgG2, we observed no IgG4-type ANA. In systemic autoimmune diseases, subclasses of ANA were mostly IgG1, 2, or 3, but IgG4-type ANA was very rarely detected. We also found several patients in whose serum ANA patterns differed among IgG subclasses, probably due to the difference of corresponding autoantigens. Conclusions: Although IgG4 is highly elevated in sera of IgG4-RD patients, their ANA do not include IgG4 subclass. These results offer new insight into the role of IgG4 and the pathogenesis of IgG4-RD, implying that each IgG subclass tends to cover its own spectrum of antigens, and IgG4 is not preferentially used to make ANA.
- Subjects
ANTINUCLEAR factors; IMMUNOGLOBULINS; PLASMA cell diseases; AUTOIMMUNE diseases; AUTOANTIBODIES
- Publication
BMC Musculoskeletal Disorders, 2015, Vol 16, Issue 1, p1
- ISSN
1471-2474
- Publication type
Article
- DOI
10.1186/s12891-015-0584-4